Results from a phase I/Ib trial of enzalutamide and gemcitabine and cisplatin in metastatic bladder cancer (mBC)

Answers

Answer 1

Promising results were obtained from a Phase I/Ib clinical trial investigating the combination of enzalutamide, gemcitabine, and cisplatin in the treatment of metastatic bladder cancer (mBC).

Enzalutamide is an androgen receptor inhibitor, while gemcitabine and cisplatin are chemotherapy agents commonly used in bladder cancer treatment. The trial demonstrated encouraging efficacy and tolerability of the combination therapy in patients with m BC. The regimen showed favorable response rates and progression-free survival, indicating potential benefits for patients with this aggressive form of cancer. These results provide a basis for further investigations and potential advancements in the management of metastatic bladder cancer. and cisplatin in the treatment of metastatic bladder cancer (m BC).

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Related Questions

if a persons blood with unknown blood type is mixed with antibodies for a antigen and no agglutination has occurred. The blood group might be:
a-A    b-B   c-O   d-both(b&c)​

Answers

I'm not sure, but I think it's a-A

SOMEBODY PLEASEEE HELP MEEEE I WILL MARK BRAINLY IF CORRECTTTT PLEASE
The images show two samples of the mineral gypsum.
Which two statements are true?
A. The samples are the same color.
B. The samples have the same streak.
c. The samples both have a metallic luster.
D. The samples have the same hardness.

SOMEBODY PLEASEEE HELP MEEEE I WILL MARK BRAINLY IF CORRECTTTT PLEASEThe images show two samples of the

Answers

Answer:

The answer is either C or D. Hope this helps. Can I have brailiest if I am right, please?

Explanation:

Answer:

B and D.

I hope this helps!

A gardener cuts the main stem of a plant, stimulating hormones in the plant that will affect plant growth. Which statement describes how the plant will most likely grow as a result?
Seeds from the plant will germinate faster.
Fruits on the plant will not develop.
The plant buds will become inactive.
Lateral leaf growth will start on the plant.

Answers

Answer: D

Explanation: Lateral leaf growth will start on the plant.

Answer:

d

Explanation:

Which function is mostly performed in the fleshy tissue parts of a plant, rather than in the tissues that make up the upper layer of leaves

Answers

Storage function is commonly performed in the part of the fleshy tissues parts of plant.

Apart from that the tissues which make up the part of the upper layers of the leaves.

Hence it can grow well and provide best answer for the question in a fine manner.

What are tissues ?

A collection of cells with similar structures and functions is referred to as a tissue. The intercellular matrix, a nonliving substance, fills the spaces between the cells. There might be a lot of this in some tissues and not much in others.

Epithelial, connective, muscular, and nerve tissues are some of the main categories of bodily tissues. All body surfaces are covered in epithelial tissues, which also line bodily cavities and hollow organs and make up the majority of glandular tissue.

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How can using a dam as a source of freshwater also harm agricultural
resources?
O A. Dams can help control floodwaters.
B. Dams can displace organisms.
C. Dams can collect topsoil during floods.
D. Dams can damage existing habitats.

Answers

Using dams as freshwater sources can damage existing habitats.

What is the Environmental Impact of dams?

Freshwater habitats are severely harmed by dams, which has an impact on both humans and the environment. Dams, canals, and diversions already stop the flow of 60% of the world's major rivers. Dams and the infrastructure they are associated with, including irrigation systems, are a major cause of the disappearance of numerous freshwater habitats and species.

Dams cut off rivers from their marshes and floodplains. Freshwater ecosystems may suffer catastrophic harm. They affect fish migration patterns and inundate riparian habitats such as waterfalls, rapids, riverbanks, and wetlands. Dams alter the diversity and productivity of species by impeding the natural flow of sediment to deltas, estuaries, flooded forests, wetlands, and inland seas. Water quality is impacted by dam activities as well. Retention of water and sediment has an impact on the capability of rivers to handle waste and the quality of the water (the ability to break down organic pollutants). This might result in the creation of harmful hydrogen sulfide gas, further lowering the quality of the water.

Hence, the answer is, D. Dams can damage existing habitats.

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Observe initial conditions at points A and B (upland, top), and C and D (lowland, bottom). Which TWO of the points on the graphs represent initial conditions that will result in one of the species being driven to extinction?
a. A and B
b. A and C
c. C and D
d. B and D

Answers

Initial conditions at points A and B (upland, top), and C and D (lowland, bottom) which represent the initial conditions that will result in one of the species being driven to extinction are options c. C and D, and option b. A and C.

The process in which an entire species of living organisms disappears from Earth is known as extinction. Extinction is the final stage of a long process of population decline that might occur over thousands or millions of years. Many species, especially single-celled organisms, have gone extinct during Earth's long history. Many other species have survived for millions of years but are currently endangered or vulnerable due to human activity.

The term "population" refers to a collection of individuals of the same species in a particular location. Members of a population compete for resources, including food, space, and water, as well as mates. These competitions can be fierce, resulting in population growth and decline depending on a variety of factors.

When a population is expanding or shrinking, the environment is the primary factor driving the changes in population size. The ability to model population growth and decline is critical to the field of ecology.

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what occurs when organisms of two species that have homologous chromosomes mate and produce ( f1 ) hybrid offspring?

Answers

When animals of two species that have homologous chromosomes marry and generate (F1) hybrid offspring, 50% of the DNA in the resulting child originates from each of the parent species.

One homolog in an F1 hybrid contains 50% DNA from one parent species and the remaining 50% DNA from the other parent species. EXPLANATION: The F1 hybrid is a product of the first generation.  Because the chromosomes from each species cannot pair properly during meiosis, the resulting hybrid is typically sterile.

Additionally, the two different species may contribute different chromosome counts, which once more prevents chromosome pairing during meiosis and renders the hybrid sterile. Due to having various alleles of the same gene, two homologous chromosomes can be distinguished from one another.

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Do you think the representations in the media of the identification and analysis of physical evidence are accurate based on the information you learned in this lesson? Why or why not?

Answers

The representations in the media of the identification and analysis of physical evidence are accurate based on the information learnt due to the various investigations and tests which occurs.

What is Evidence?

This is referred to the materials and information which helps to prove that something is true or valid and at crime scenes, fingerprint and blood are usually collected so as to solve the investigation.

However, the representations in the media of the identification and analysis of physical evidence are usually well analysed after series of thorough investigations and tests have been done so as to ascertain the true story and picture before it is then divulged to the public.

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Please help ASAP
Which of these is NOT an example of an environmental factor that can affect an organism's growth?

Inheriting the gene for purple flower petals
or
Limited or no shelter/space to nurture offspring
or
inadequate sunlight
or
insufficient access to water or nutrients

Answers

inheriting the gene for purple flower petals

Where is the genetic material of a bacterium found.

Answers

Answer:

The DNA of most bacteria is contained in a single circular molecule, called the bacterial chromosome. The chromosome, along with several proteins and RNA molecules, forms an irregularly shaped structure called the nucleoside. This sits in the cytoplasm of the bacterial cell.Explanation:

FILL IN THE BLANK. complexing with calcium dipicolinate and small acid-soluble proteins (sasps) are mechanisms that protect the ___ of an endospore from harsh environmental conditions.

Answers

Complexing with calcium dipicolinate and small acid-soluble proteins (sasps) are mechanisms that protect the _DNA__ of an endospore from harsh environmental conditions.

What is DNA of an endospore?

DNA of an endospore is the genetic material present inside the endospore, which is a dormant and highly resistant structure formed by some bacterial species.

Endospores are formed as a survival strategy in response to harsh environmental conditions and they can persist for long periods of time until conditions become favorable for germination.

DNA of an endospore is protected from the environment by complexing with calcium dipicolinate and small acid-soluble proteins (sasps), which helps to maintain the stability and integrity of the genetic material.

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Kendrick holds the rubber blue ball halfway up the ramp and releases ir (figure 1).The ball rolls down the ramp and along the floor beyond the end of the ramp. What force caused the ball to roll down the ramp?

Answers

The force that caused the rubber blue ball to roll down the ramp is gravity. When Kendrick held the ball halfway up the ramp and then released it, the force of gravity began to act on the ball and it started to roll down the ramp.

A ramp is an inclined plane that reduces the amount of force required to move an object to a higher level. The force of gravity, which is an attractive force between any two objects in the universe, acts on objects in the direction of the center of the Earth.

This force causes objects to fall toward the ground. When the rubber blue ball was released from the midpoint of the ramp, it began to move in the direction of the force of gravity, which caused it to roll down the ramp. The force of gravity was able to overcome the ball's inertia and caused it to accelerate down the ramp. Once the ball rolled off the end of the ramp, it continued to move forward due to its inertia.

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in what trophic level is the wombat in

Answers

The highest trophic level called the tertiary consumers

SOS
summarize the effects of human population growth and catastrophic events on ecosystems
describe the sources, types, and effects of varying pollutants
assess the consequences of loss of biodiversity
explain the term sustainable development and describe some of its resource

Answers

Answer\Explanation

Humans impact the physical environment in many ways: overpopulation, pollution, burning fossil fuels, and deforestation. Changes like these have triggered climate change, soil erosion, poor air quality, and undrinkable water.Housing and feeding so many people has accelerated the destruction of natural habitats, while higher levels of consumption, particularly in some richer parts of the world, have also increased the exploitation of natural resources and led to growing levels of pollution.

what are the 4 Chambers of heart?​

Answers

Answer:

The four chambers of the heart are the two upper and two lower chambers.

Explanation:

The four chambers of the heart are the two upper and two lower chambers.

The upper chambers are the right atria and the left atria, and the two atrias receive blood. The lower chambers are the right and left ventricles, and the two ventricles pump blood out of the heart.

Answer:

The heart is divided into two parts atrium and ventricle. We have left atrium, right atrium, left ventricle and right ventricle.

which of the following most accurately describes the function of a vaccine​

Answers

Answer:

to protect you from getting an effaction

to protect you from getting from infection by pathogen is  accurately describes the function of a vaccine​

what are the types of vaccine ?

A vaccine can be defined as a biological preparation which provide an active acquired immunity to a specific infectious and transmissible disease.

A vaccine consist of an agent that has a similarity to the disease-causing microbe. Inactivated Vaccine are formed by inactivating a pathogen by applying heat or chemicals such as formaldehyde or formalin, it destroys the pathogen’s ability to replicate.

Attenuated vaccines are formed from different ways like passing the disease-causing virus through a series of cell cultures or animal embryos.

Toxoid Vaccine can be made by inactivating the toxin released from bacteria that causes disease symptoms, the organisms or viruses used in inactivated vaccines which can be done via treatment with a chemical such as formalin.

Subunit Vaccine use a part of a target pathogen to provoke a response from our immune system, which can be done by isolating a specific protein from a pathogen.

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What characteristic of double-stranded DNA determines the ability of one strand to make an exact copy of the other strand?

O complementary pairing of bases

O hydrogen bonding between strands

O ability of bases to be connected in any order

O location of the base pairs in the center of helix

Answers

Answer:

The correct answer is ''complementary pairing of bases''

Explanation:

The double-stranded DNA with the complementary nitrogenous bases that are located inwards and establish non-covalent bonds (or attractive forces) to each other that maintain the structure of the molecule. Deoxyriboses (sugars) and phosphate groups constitute the columns of the molecule. When the cell divides, each new cell that is formed must carry all the genetic information that determines its characteristics and functions. For that, before dividing, DNA must replicate, that is, generate a copy of itself. During replication, the DNA molecule unwinds, separating its chains. Each of these will serve as a template for the synthesis of new DNA strands. The double-stranded DNA structure proposed by Watson and Crick (1953) suggested several important properties of the hereditary material: Complementarity rules of the nitrogenous bases A-T and G-C suggest a simple way of replication of the hereditary material. This simple form of replication is called a semi-conservative method. When DNA replicates, its two helices separate and each one of them serves as a template to synthesize a new helix following the pairing rules of nitrogenous bases.

What is the central idea of this passage on the third Sunday after Snowball's expulsion?

Answers

The animals cannot comprehend Snowball's disappearance. Napoleon wants the animals to put forth more effort and consume less food. third Sunday following Snowball's expulsion

What do you mean by expulsion?

Expulsion is the common noun for expulsion, which means to push out. Expel and eject are related verbs, but expel denotes pushing out because eject denotes flinging out. Additionally, ejection might just be temporary: although a student who is expelled form school is likely gone for good, the player who was expelled from a game might return the next day.

what level  from Expulsion ?

The three stages of labor are: the dilatation stage, the ejection stage, and the placental stage. The dilatation (opening) stage lasts the longest, followed by the expulsion (pushing out), which lasts 30 to 60 minutes, and the placental stage, which can last anywhere from a few minutes to an hour.

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3. Select the dependent variable for answering the stated research question.
Hint: Research Question - "To what extent do respiration rates for various organisms differ at 12-15°C?"
The amount of carbon dioxide produced
The different types of organisms
The different temperature settings
The amount of time the experiment runs

Answers

DONT WORRY

ANSWER KO YAN NG MADALI

PERO BRAINLIEST MUNA

MUAAAAAH

TENCHUUUU

Which of the following is a true statement? A. Both electric fields and electric forces maintain their strength at the distance increases. B. Both electric fields and electric forces increase in strength as the distance decreases. C. Electric fields don't change in strength with distance from a charge, but electric forces do. D. Electric forces stay the same as distance changes, but electric fields change.​

Answers

I think it’s B to be honest

Enzo works in the primate exhibit in a city zoo. Recently, the zoo has installed a wire tunnel that hangs through the trees and eventually ends in an extra habitat on the other side of the park. Since these have been opened, the two male orangutans, Kwame and Ikon, have gotten into fewer fights. What conclusion would this MOST likely cause Enzo to reach about the primates?

A.
Having more room to spread out has decreased irritation between the orangutans.

B.
The new environment has fooled Kwame and Ikon into thinking they are in the wild.

C.
Kwame and Ikon are concerned that they may be separated if they do not behave.

D.
The orangutans are distracted by more tourists because of the new exhibit.

Answers

Enzo's conclusion regarding the primates is most likely to be that they are less irritable now that they have more habitat to spread out.

The construction of the wire tunnel that runs through the trees and connects to a second habitat on the opposite side of the park gives the primates such as orangutans greater room to roam and explore, which can lessen the likelihood of fights and violent behavior.

Consequently, it is reasonable to infer that the greater space and more habitat offered to them are the causes of the decrease in conflicts between Kwame and Ikon.

Therefore, the correct option is A.

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2 Natures of Insular Biotas?

Answers

The two natures of insular biotas refer to their isolation and unique ecological characteristics. Insular biotas are typically isolated from mainland ecosystems and have evolved in distinct ways due to their insularity.

Two natures of insular biotas are:

1. Isolation: Insular biotas, being located on islands or isolated areas, experience limited interaction with other ecosystems. This results in unique species compositions and adaptations due to the absence of certain external influences.

2. Endemism: Insular biotas often have high levels of endemism, meaning many species found in these ecosystems are unique to that specific location. This is a result of the isolation, which allows species to evolve independently from their mainland counterparts.

This isolation has led to the development of unique species and communities, as well as increased vulnerability to threats such as invasive species and habitat loss.

The insular nature of biotas also means they are often more sensitive to environmental changes, making conservation efforts crucial for their survival.

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The purpose of both mitosis and melosis is to create new cells. Both processes involve the replication of genetic material within the cell; and bith take opace within a sexually reproducing individual. There is a difference between the processes, however What is one crucial difference?
A-Meiosis creates an exact replica of the parent cell, while mitosis shows genetic diversity
B-Mitosis creates an exact replica of the parent cell , while meiosis shows genetic diversity .
C-Only meiosis allows for the possibility of gene point mutations .
D-Only mitosis allows for the possibility of translocation .

Answers

Answer: B or A

Explanation:

which of the following please help me ​

which of the following please help me

Answers

Answer:

the highest structural level in the elephant body is the foot

Summarize how mutation violates the Hardy-Weinberg principle.

Answers

Answer:

Mutations must not occur to introduce new alleles to the population. No gene flow can occur to increase variability in the gene pool. A very large population size is required to ensure allele frequency is not changed through genetic drift. Mating must be random in the population.

HOPE THIS HELPS PLEASE MARK ME BRAINIEST

Tsunamis are...
Wind currents
a long, high-water wave caused by a disturbance on the floor of the ocean or
large lake
the tides pulling on the water
an excess of rain

Answers

Answer:

B

Explanation:

because I know

Answer:
Option B.

Explanation:

Why?

A is incorrect
Large tsunami tides are not made by ocean currents. The wind has little to no effect in a tsunami. Like making waves in a pool of water, there is a required disturbance that causes the water to move.  

C is incorrect.
It has to do with disturbances but its not quite the response were looking for.

D is incorrect.
Option D is describing a flood. in large bodies of water like a big lake or pond, you'll find that to be the case.

Tsunamis are created by a disturbance in the ocean floor. Much like earthquakes, the ocean experiences new plate formation and movement.

In red blood cells, lactate is continually produced as a consequence of their anaerobic metabolism. What is the energetic cost (to the liver) in ATP of converting this lactate back to glucose, per molecule of glucose generated?

Answers

The energetic cost of converting lactate back to glucose per molecule of glucose generated is 6 ATPs.

Lactate is produced by anaerobic respiration in muscles when oxygen demand exceeds supply, causing fatigue. The liver converts the lactate back to glucose, which muscles can utilize for further energy production. There are two main pathways that produce ATP in human cells: aerobic respiration (requiring oxygen) and anaerobic respiration (not requiring oxygen).

During anaerobic respiration, energy is obtained from glucose without the use of oxygen. As a result of anaerobic metabolism, red blood cells generate lactate. Red blood cells are the only mammalian cells that lack mitochondria and consequently depend solely on anaerobic metabolism for energy production. This reliance on anaerobic metabolism has significant consequences, with lactate being continually produced as a byproduct.

The liver is responsible for converting lactate back to glucose in a process known as gluconeogenesis. It is an ATP-intensive process that consumes 6 ATP molecules per molecule of glucose generated, according to research.

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place the following steps of polysaccharide chain cleavage by lysozyme into the correct order. 1) Lysozyme and products dissociate 2) Lysozyme and substrate form an enzyme-substrate complex, forcing one sugar molecule into a strained conformation. 3) Glutamic acid donates a proton to one sugar as aspartic acid attacks the C1 carbon of a second sugar. 4) Glutamic acid donates a proton to one sugar as aspartic acid attacks the C1 carbon of a second sugar. 5) The water oxygen attacks the C1 carbon, breaking the sugar- aspartate bond. 6)Glutamic acid polarizes a water molecule, drawing a proton away from the water. 7) A covalent bond forms between the aspartic acid and the sugar, and the sugar-sugar bond is hydrolyzed.

Answers

Lysozyme and substrate form an enzyme-substrate complex, forcing one sugar molecule into a strained conformation. Glutamic acid donates a proton to one sugar as aspartic acid attacks the C1 carbon of a second sugar.

A covalent bond forms between the aspartic acid and the sugar, and the sugar-sugar bond is hydrolyzed. The water oxygen attacks the C1 carbon, breaking the sugar-aspartate bond. Glutamic acid polarizes a water molecule, drawing a proton away from the water. Lysozyme and products dissociate. The correct order of steps of polysaccharide chain cleavage by lysozyme are as follows: Lysozyme and substrate form an enzyme-substrate complex, forcing one sugar molecule into a strained conformation. Glutamic acid donates a proton to one sugar as aspartic acid attacks the C1 carbon of a second sugar.

A covalent bond forms between the aspartic acid and the sugar, and the sugar-sugar bond is hydrolyzed. The water oxygen attacks the C1 carbon, breaking the sugar-aspartate bond. Glutamic acid polarizes a water molecule, drawing a proton away from the water. Lysozyme and products dissociate. Lysozyme is an enzyme that breaks down glycosidic bonds in bacterial cell walls. The enzyme binds to a sugar molecule in the substrate and rearranges it into a strained conformation when it binds to it .The enzyme's glutamic acid donates a proton to one sugar in the substrate, while its aspartic acid attacks the C1 carbon of a second sugar.  A covalent bond forms between the aspartic acid and the sugar, breaking the sugar-sugar bond.

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Relate dark matter to the development of the universe after the Big Bang. In 3-5 sentences, speculate on how the development of the universe would have been different if there had been no dark matter. In your answer, use the term structures.

Answers

The development of the universe would not be able to move or function if there had been no dark matter.

What is Universe?

This is referred to as the space, energy and matter present in space and is also everything we can feel, touch or see. Examples of the constituents include stars, planet etc and they have their unique properties and functions.

Without the presence of the dark matter in the universe, there will be no formation of  the larger versions of those galaxies and the universe won't be able to move or function thereby making it the correct choice.

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HELP QUICK PLEASE!!!!!

HELP QUICK PLEASE!!!!!

Answers

Answer:

try C

Explanation:

it supports laws that protect the public from environmental hazards

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How does Alecs arrival at the cabin affect the events of the story? ruthless What is the solution of 0.2x - 4 - 2x < -0.4 and 3x + 2.7 M is the midpoint of the diagonals. Use the properties of rotations to show that the measures of both pairs of opposite sides are equal in length. Aidan put $3000 into a savings account that earns 6% interest. After six years, now much miney will Adian have? Read the passage from Sugar Changed the World. Sugar is a taste we all want, a taste we all crave. People throughout the planet everywhere have been willing to do anything, anything at all, to get that touch of sweetness. We even know exactly how thrilling it was to taste sugar for the first time. When the Lewis and Clark Expedition met up with the Shoshone, who had little previous contact with Old World products, Sacagawea gave a tiny piece of sugar to a chief. He loved it, saying it was "the best thing he had ever tasted." Sugar created a hunger, a need, which swept from one corner of the world to another, bringing the most terrible misery and destruction, but then, too, the most inspiring ideas of liberty. Sugar changed the world. We begin that story with a man who could never know enough. How does the conclusion of the prologue support the authors purpose? Select two options. It introduces the topic that will be addressed next. It provides information about the authors. It states why the topic is relevant to readers. It cites sources the authors used in the text. It explains how the authors came to study the subject. Which file(s) do you need to encrypt? Select all that apply. A.txt B.docx C.bmp D.xlsx E.pub F.pptx At what value should a nongovernmental not for profit organization record shares of stock when received? An employee works 37 regular hours during a workweek in August of 2021. He was hired four years ago, earns a salary of $140,200/year, and is exempt from the overtime provisions of the FLSA. To date, he has received no compensation beyond his annual salary. He has requested that his employer withhold 8% of gross pay, which is to be contributed to a 401(k) plan Giving brainlyist to the first to answer with a correct and complete answer. b. Look at the vector G below.Answer both of the questions pleaseee. 40 points!!!!!! And dont try to steal them bc you will f regret it. 40 points!!!!! Fill in all the blanks plz and be specific where each number goes 2. A Normal probability plot of a set of data is shown here. Would you say that these measurements are approximately Normally distributed? Why or why not? (10 Marks) PLS ANSWER FASTER The total amount of sunlight that approaches earth is about __________ in June as in December. A - half as muchB - the sameC - twice as much What is the magnitude (size) of 3.7?O A. 0.37, because 13.7= 0.37O B. 3.7, because |3.7= 3.7O C. 3.7, because 13.71 = -3.7O D.-3.7, because |3.7) = 3.7 Which symbol correctly compares these fractions?9 3610 40 You have just retired with savings of $1 million. If you expect to live for 49 years and to earn 10% a year on your savings, how much can you afford to spend each year (in $ dollars)? $_ (Assume that you spend the money at the start of each year.) as control risk increases, the amount of substantive evidence the auditor plans to accumulate should increase. question content area bottom part 1 true false How many moles of BaCl2 are in 56g of BaCl2? Which of the following statements is true? O A fixed charge is usually created over the immovable assets of the company and it allows the company to deal with and dispose these assets in the ordinary course of business. O A floating charge is usually created over the movable assets of the company and it prevents the company to dispose these assets without the bank's approval. O The company can dispose its movable assets when it foresees that the mortgagee is going to crystallise the floating charge. O None of the options. What is the value of X