pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

Answers

Answer 1

Osteoporosis is the disease of the low bone mass and most often caused by the increase in the bone resorption that is not in sufficiently compensated for by the corresponding increase in the bone formation. As result gut-derived serotonin (GDS) inhibits the bone formation, we can asked whether hampering its is biosynthesis that could treat the osteoporosis through the anabolic mechanism (that is, by increasing bone formation).

We can synthesized and used the LP533401, a small of molecule inhibitor of the tryptophan hydroxylase-1 (Tph-1), the initial enzyme in the GDS biosynthesis. or the Oral administration of this small molecule once daily for up to the six weeks that acts as prophylactically or therapeutically, in the dose-dependent manner, to treat the osteoporosis in the ovariectomized the rodents because of an isolated increase in the bone formation. These results that provide a proof of the principle that have inhibiting the GDS biosynthesis that could become a new anabolic and treatment for osteoporosis.

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Related Questions

Internal TR NSB Sc 35. Transcription factors in eukaryotes usually have DNA binding domains as well as other domains that are specific for binding other types of molecules. In general, which of the following would you expect many of them to be able to bind? A) repressors B) ATP C) protein-based hormones D) other transcription factors E) tRNA

Answers

In general, many transcription factors in eukaryotes are expected to be able to bind to other transcription factors. Option D is the correct answer.

Transcription factors often interact with each other to form complexes and regulate gene expression. They can act as activators or repressors of transcription depending on the specific DNA sequences they bind and the cofactors they recruit.

By binding to other transcription factors, they can modulate their activity and coordinate the expression of target genes. While transcription factors can also interact with repressors, protein-based hormones, and other molecules, the binding to other transcription factors is a common and crucial mechanism for regulating gene expression in eukaryotic cells.

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During which period of time does a eukaryotic cell replicate its DNA?
A. The S phase of the cell cycle
B. Anaphase of mitosis
C. Prophase of mitosis
D. The G2 phase of the cell cycle

Answers

Answer:

A, The S phase of the cell cycle

Explanation:

The S phase is the phase of DNA synthesis

hemophilia, a blood-clotting disorder in humans, is an x-linked recessive trait. if a normal man has a son with a carrier woman, what is the probability that the son will have hemophilia?

Answers

The probability that the son will have hemophilia is 50%.

Since the mother is a carrier of the hemophilia gene, she can pass either the normal X chromosome or the X chromosome with the hemophilia gene to her son. The father, who does not carry the hemophilia gene, will always pass a normal X chromosome to his son. Thus, there are two possible outcomes for the son's genotype: he will either receive a normal X chromosome from both parents and not have hemophilia, or he will receive the X chromosome with the hemophilia gene from his mother and be affected by the disorder. Therefore, the probability of the son having hemophilia is 50%. It is important to note that this probability only applies to each individual son and not to a group of sons.

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How many calories do I need to gain muscle i am 75 pounds and 4 foot 5

Answers

Answer:

is there a reon why u want to gain mucle

Explanation:

Just follow a plan that best suits you! Best of luck!

Which of the following is not a transboundary health hazard along the u.s.-mexico border? a. abandoned tires b. raw sewage c. animal carcasses d. hazardous waste

Answers

Answer:

A) abandoned tires

Explanation:

Abandonded Tires are not a transboundary health hazard. Exposure to the vapors emitted by raw sewage can lead to gastroenteritis and E.Coli. Dead animal carcasses can carry several diseases that are detrimental or even deadly for humans. Hazardous substances may irritate the skin or eyes, make it difficult to breathe, and even cause cancer.

Answer:

a

Explanation:

ed

Which is the change in size of a group of organisms of the same species over time?
-population growth
-death rate
-birth rate
-immigration and emigration

Answers

The change in size of a group of organisms of the same species over time is called population growth (option A).

What is population growth?

Population growth is the change in size of a group of organisms of the same species over a particular time.

The population growth rate also called the rate of increase or per capita growth rate equals the birth rate minus the death rate divided by the initial population size.

The population growth rate can be symbolized as follows: ∆P i.e. change in population size.

A population can be affected by the following;

Death rateBirth rateImmigrationEmigration

Therefore, population growth is the change in population size of the species of that population.

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Answer:

The change in size of a group of organisms of the same species over time is called population growth

Explanation:

two hormones secreted by the ovaries that are responsible for menstrual cycle and menopause are:

Answers

The two hormones secreted by the ovaries responsible for the menstrual cycle and menopause are estrogen and progesterone.

Estrogen  is responsible for the development and maintenance of female reproductive structures and secondary sexual characteristics. During the menstrual cycle, estrogen levels fluctuate, promoting the thickening of the uterine lining (endometrium) in preparation for potential implantation of a fertilized egg. It also plays a role in the maturation of the ovarian follicles and triggers ovulation.

Progesterone works in conjunction with estrogen during the menstrual cycle. After ovulation, progesterone levels increase and support the preparation of the uterine lining for implantation. If fertilization occurs, progesterone helps maintain the pregnancy. If fertilization does not occur, progesterone levels drop, leading to the shedding of the uterine lining and the onset of menstruation.

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Marc plans to create a model of the solar system for his school’s science fair. He knows the solar system includes many celestial bodies.

Which statement identifies a possible limitation of this model?

A. The model will be supported with scientific evidence.
B. The model will include all planets of the solar system.
C. The model will be used to predict planet distances and sizes.
D. The model will oversimplify what the solar system looks like.

Answers

Answer:

B. The model will include all planets of the solar system.

Explanation:

Answer:

not fs but i heard D

Explanation:

nobodys saying A at all

b and c seem off could be wrong. just lmk

what are the funtions and parts of the skeletal system?

Answers

Answer:

I'm actually working on this as well, haha!

Explanation:

The skeletal system can help protect internal organs from injury. For example, the skull protects the brain, while the thoracic cage protects the heart and lungs.

True or false: Organisms in kingdoms fungi are eukaryotic?

Answers

Answer:

Is true;
Fungi
Fungi are eukaryotic organisms that comprise one of the largest kingdoms known. Fungi are capable of forming large networks and are nearly ubiquitous in the world around us, present in the air and underground.


Mention the types of bees​

Answers

Answer:

ok thus very good percent few Mohammad khan

the hypothalamus controls the posterior pituitary by way of __________.

Answers

The answer is neuroendocrine reflexes

the doctrine of superiority by which one group justifies the dehumanization of others based on their distinctive physical features in

Answers

The doctrine is called "racial superiority," which is the belief that one race or ethnic group is inherently superior to others based on physical or cultural differences. This belief has been used historically to justify the dehumanization and oppression of minority groups, leading to discrimination, segregation, and even genocide.

In this context, the group claiming superiority uses the doctrine as a way to rationalize their actions and maintain a sense of entitlement and control over the marginalized group leading to the dehumanization of others . This belief system is often fueled by prejudice, stereotypes, and a desire to maintain power and dominance. Steps to counteract this harmful doctrine include promoting education and awareness, fostering empathy and understanding, and advocating for equal rights and opportunities for all individuals, regardless of their physical features.

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The concept you're describing is known as racial or ethnic superiority, which is a belief system that asserts the superiority of one group over others based on their distinctive physical features. This doctrine often leads to the dehumanization and marginalization of certain groups, reinforcing social inequalities and perpetuating discrimination.

The doctrine of superiority refers to the belief that one group of people is inherently better or more valuable than another. This belief can manifest in various ways, but one common form is the idea that certain physical features or characteristics make one group superior to others. This justification for dehumanization is often used to justify discrimination, oppression, and even violence against those who are perceived as different. Examples of such physical features might include skin color, ethnicity, or religion, and the dehumanization can take many forms, such as denying basic rights and freedoms, or treating individuals as objects rather than human beings. Ultimately, this doctrine of superiority is a deeply harmful and dangerous belief that must be challenged and dismantled in order to create a more just and equitable society.

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Nitrogen from animal wastes or plant an animal tissue
O must be fixed near leguminous plants,
O is lost from the system.
O is fixed by bacteria and fungi in the soil.
O is already fixed and can be used.

Answers

System is okay better

Nitrogen from animal wastes or plant an animal tissue  is fixed by bacteria and fungi in the soil.

So, option C is correct one.

How plants and animals get nitrogen ?Since our atmosphere contains 78% of nitrogen but it is very difficult  to take directly by plants and animals.Nitrogen is very essential for all living organism.Plants take nitrogen from soil.Some bacteria and fungi are present in the soil who fix nitrogen from the atmosphere and convert it into nitrogen compound.Then this nitrogen from the soil by root system of the plants.Now plant use this nitrogen for synthesis of proteins and other compounds.Animals who feed plants gets this proteins and other nitrogen compound from plants.When plants and animals die , fungi and bacteria present in the soil converts this nitrogenous waste into nitrogenous compound and reuse of nitrogenous compound is repeated again.

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Sister chromatids of a pair of homologous chromosomes form tetrads, and crossing-over (exchange of genetic information between regions of non-sister chromatids in the tetrad) occurs during which phase

Answers

Crossing over (exchange of genetic information between regions of non-sister chromatids in the tetrad) occurs in the prophase I stage of meiosis.

WHAT IS MEIOSIS?

Meiosis is the process whereby a single cell produces four daughter cells that are genetically different from one another.

Meiosis is able to ensure genetic diversity in the daughter cells due to a process called Crossing over.

Crossing over is the exchange of genetic material between the non-sister chromatids of homologous chromosomes. It occurs in the prophase I stage of meiosis.

Therefore, crossing over (exchange of genetic information between regions of non-sister chromatids in the tetrad) occurs in the prophase I stage of meiosis.

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What is a polar molecule?

Answers

Answer:

This your answer below the image!!!

Explanation:

What is a polar molecule?

Amylase is secreted in two regions of human alimentary. Why? Support your answer
with scientific evidence.

Answers

Answer:

Amylase is an enzyme that is involved in the breakdown of complex carbohydrates into simple sugars such as glucose. It is secreted in two regions of the human alimentary canal: the mouth and the pancreas

Explanation:

In the mouth, amylase is secreted by the salivary glands and begins the process of breaking down starch into maltose. the pancreas, amylase is produced and secreted into the small intestine. The pancreas produces both pancreatic amylase and salivary amylase, but the pancreatic amylase is more important because it can break down the remaining complex carbohydrates that have not been fully digested in the mouth. This is necessary because the small intestine is the primary site of nutrient absorption, and carbohydrates must be broken down into simple sugars before they can be absorbed by the body.

Amylase is secreted in two regions of the human alimentary canal because carbohydrates are present in different forms and need to be broken down into simpler forms before they can be absorbed by the body

The myenteric plexus regulates movement of smooth muscle and the submucosal plexus _____.

A. stimulates mucous secretions to help with lubrication within the lumen and contraction of the muscularis mucosae.

B. helps the pancreas regulate blood glucose concentration.

C. Regulates the sphincters within the stomach to open and close.

D. stimulates gastric secretion in the stomach only.

Answers

The myenteric plexus regulates the movement of smooth muscle in the gastrointestinal tract, while the submucosal plexus stimulates mucous secretions to help with lubrication within the lumen and contraction of the muscularis mucosae, option A is correct.

The submucosal plexus stimulates mucous secretions to help with lubrication within the lumen and contraction of the muscularis mucosae. This plexus is located in the submucosa of the gastrointestinal tract and plays a crucial role in coordinating various digestive processes.

It regulates the secretion of mucus, which helps lubricate the inner lining of the digestive tract, facilitating the movement of food along the tract. Additionally, the submucosal plexus controls the contraction of the muscularis mucosae, which aids in the mixing and absorption of nutrients, option A is correct.

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Length of bone decreases due to a reduced rate of ____________ by osteoblasts. Consequently, the relative amount of inorganic minerals in the bone matrix ____________ . The bones of the skeleton become ____________ and susceptable to ____________ . Second, bone ____________ (loses calcium and other minerals). The bones of the skeleton become thinner and weaker, resulting in insufficient ____________ , a condition called ___________________.

Answers

Length of bone decreases due to a reduced rate of bone formation by osteoblasts. Consequently, the relative amount of inorganic minerals in the bone matrix decreases. The bones of the skeleton become more porous and susceptible to fractures. Second, bone resorption increases (loses calcium and other minerals). The bones of the skeleton become thinner and weaker, resulting in insufficient bone density, a condition called osteoporosis.

The length of a bone is primarily determined by the process of bone formation, which involves the activity of specialized cells called osteoblasts. Osteoblasts are responsible for synthesizing and depositing new bone tissue, contributing to bone growth and remodeling. When the rate of bone formation by osteoblasts decreases, it can lead to a reduction in the length of the bone.

In addition to contributing to the overall structure of bone, there are inorganic minerals, such as calcium and phosphate, present in the bone matrix. These minerals provide strength and rigidity to the bone. However, when the rate of bone formation decreases, the relative amount of inorganic minerals in the bone matrix also decreases. This reduction in mineral content makes the bones less dense and more porous, which compromises their strength and increases their susceptibility to fractures.

Furthermore, bone remodeling involves a balance between bone formation and bone resorption. Bone resorption is the process of breaking down bone tissue by cells called osteoclasts. When bone resorption outpaces bone formation, the net result is a loss of calcium and other minerals from the bone. This contributes to the thinning and weakening of the bones, further increasing the risk of fractures.

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According to the Foliated Metamorphic Rock Chart slate, phyllite, schist, and gneiss can all have the same parent rock (shale). If this is true, what determines the difference between a slate and a gneiss rock that both are formed from shale? What role does the parent rock play in determining the type of metamorphic rock that will be formed? In a rock that has undergone contact metamorphism, would you expect to find foliation? Why or why not? State your answers in 3-5 sentences.

please answer simply! Thank you so much! I will name brainiest!

Answers

The difference between a slate and a gneiss rock that are both formed from shale is due to the degree and type of metamorphism they undergo. Slate has undergone low-grade metamorphism, while gneiss has undergone high-grade metamorphism.

The parent rock plays a role in determining the type of metamorphic rock that will be formed as the mineral composition and texture of the parent rock will affect the metamorphic process.

What is the rock about?

In a rock that has undergone contact metamorphism, foliation may or may not be present.

Foliated metamorphic rocks, such as slate, phyllite, schist, and gneiss, are formed when the rock is subjected to directed pressure, which aligns the minerals in a parallel or foliated pattern.

However, contact metamorphism is caused by heat and typically does not involve directed pressure, so foliation may not be present in rocks that have undergone contact metamorphism.

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When our prehistoric ancestors studied the night sky they noticed that 5 objects moved through the constellations, what are these called?

Answers

Answer:

planets

Explanation:

In the past, it was observed that little points of light moved through the constellations. Nowadays, we known that these points are planets which orbit around the sun, while stars remain fixed in the sky. This phenomenon is due to the fact that planets are so much closer to the Earth than the stars. From Earth, five planets can be seen with naked eyes (i.e., Jupiter, Saturn, Mars, Venus and Mercury).

Plz help! Its due in like 10 mins!!
HELP

Plz help! Its due in like 10 mins!! HELP

Answers

Answer:

c.

Explanation:

It is showing the size of Earth's layers. There is nothing here about its chemical composition or Earth's temperature.

PLEASE HELP DUE TOMORROW!

what are the advantages of harvesting more crops and trees to reducing carbon emissions?

And what are disadvantages of harvesting tree and crops for reducing carbon emissions?

Answers

Answer:

the advantage is free more space to plant crops and farm animals and build houses

the disadvantage is destroying the animal environment and may cause climate change and killing an endangered species by destroying there houses or by accident

Answer:

As trees grow, they help stop climate change by removing carbon dioxide from the air, storing carbon in the trees and soil, and releasing oxygen into the atmosphere and more space.

The graph shows that if Jenna walks for 4 1/2 hours, she will walk blanck miles.

Answers

There is no graph attached to this question. I suggest adding one

Give two structural features that can be used to separate housefly and millipede
to respective classes​

Answers

Having wings or no wings. Second is number of legs.

(Hope this is correct and helps)

Two structural features that can be used to separate a housefly and a millipede are winged vs. wingless and legs per body segment.

What separates a housefly and millipede?

Houseflies and millipedes can be distinguished based on several key characteristics:

Body Structure: Houseflies have a compact body structure with a single pair of wings and six legs attached to the thorax. In contrast, millipedes have an elongated and segmented body with numerous pairs of legs. The number of legs in millipedes can vary, but they typically have more than six pairs.

Winged vs. Wingless: Houseflies possess fully developed wings, enabling them to fly, while millipedes lack wings and are incapable of flight. Instead, millipedes rely on their numerous legs for movement.

Habitat and Behavior: Houseflies are commonly found in diverse environments, including urban areas, where they are attracted to food sources. They are known for their ability to quickly move and hover in the air. On the other hand, millipedes are primarily found in damp environments such as forests or gardens, where they feed on decaying organic matter and vegetation.

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The oldest rocks in the ocean are near the mid-ocean ridges.

Answers

Answer:

north Atlantic ocean

is your answer

Answer:

Mediterranean ocean that's it bro

Please help, Im very confused.

Please help, Im very confused.

Answers

Answer:it should b or c hope this helps let me know

Explanation: pls give me a brainliest

a peptide bond is always between the elements:
a. hydrogen & carbon
b. oxygen & hydrogen
c. nitrogen & oxygen
d. carbon & nitrogen

Answers

Answer:

hdgdhdbvdghdhfbvxh DJ ebNBC fgdgdgd bgg fgsgshdbdbdbdbbdhdgd

Explanation:

dhshbdd

what part of the body does tuberculosis mainly affect?

Answers

Answer:

TB usually affects the lungs, but it can also affect other parts of the body, such as the brain, the kidneys, or the spine. A person with TB can die if they do not get treatment.

Which of the following is most likely to contribute to density-dependent regulation of populations? Group of answer choices Individuals voluntarily stop mating so that overcrowding does not occur. Density-independent factors lead to fewer births and increased mortality. The incoming energy decreases in populations experiencing a high rate of increase. Density-dependent factors lead to fewer births and increased mortality.

Answers

Answer:

Density-dependent factors lead to fewer births and increased mortality.

Explanation:

The carrying capacity can be defined as the maximum population size an environment can support. Density-dependent limiting factors produce a logistic growth pattern (S curve) in the population until it reaches its carrying capacity, thereby decreasing the birth rate and increasing the mortality rate in the population. Some important density-dependent limiting factors able to control the size of the population are competition (intraspecific competition), predation and diseases.

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50 POINTS PLS HELP!!!7. Write the expression as a single natural logarithm.3 ln 6 + 4 ln xln (216 + x4)ln 216x4ln 72xln 18x4 Choose a movie/streaming/ on demand released this spring 2021 or summer 2021. I does not have to be a movie currently playing and can be a movie scheduled to be released. Describe in detail who the movie is targeted to. It could be multiple groups. Describe the target in detail: age, education, income, likes/dislikes and social affiliations etc. Explain why you think these group(s) would be the target market for the specific movie you choose. Please be detailed. Part 2 Respond to the following quote from Matthew Kobach from the Linked In Account Marketing Millennials. Be specific regarding your reaction whether it is positive or negative, tell me WHY you have this opinion or feel this way. "Marketing is a humbling profession. Sometimes the idea you're certain is going to work doesn't work. Or the idea you know definitely won't work for some reason does work. 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Below is a DAB. Set up and solve an equation to find the value of X. Then find the measurement of the missing angle. two different rivers have drops that are the same height. in river a, this section of the river is a waterfall. in river b, this section has a hydroelectric dam. in what way does the energy differ between the drops in the two rivers? Give me some rapping bars give me atleast 5 verses. What is Roxies dad name in rebound book HELP ME BEFORE I GET IN TROUBLE f(x) = 1/xg(x) = x 4 Can you evaluate (g f)(0)? Explain why or why not. Wasnt there for class so I dont really know how to do this someone help :( What adaptation has arisen in sap-feeding Hemiptera to deal with dilute diets?A long stomachA filter chamberLarge mandiblesSalivary secretions You should assign a ____ name to each of the controls in a program, because doing so will help you keep track of the various objects included in the interface. For Option #2, you will be representing a map by a graph and finding the coloring of the graph that uses the fewest number of colors. Complete the following tasks:Part 1:Find the county map of New Hampshire and create a graph that represents it. Counties should be represented as the vertices and the edges should be drawn between them when two counties share a border.Determine if your graph is 2-colorable, 3-colorable, or 4-colorable.Discuss how you found your answer to part (b) and what real-world applications there might be for your findings.Part 2:Draw a map of a fictional state consisting of four counties that is 3-colorable.Discuss your method for creating the map in part (a). Be sure to explain how you verified that your map is indeed 3-colorable.Additional Requirements:Paper must be written in 3rd person.Your paper should be 3-4 pages in length (counting the title page and references page) and cite and integrate at least one credible outside source. The CSU Global Library (Links to an external site.) is a great place to find resources. Your textbook is a credible resource.Include a title page, introduction, body, conclusion, and a reference page.The introduction should describe or summarize the topic or problem. It might discuss the importance of the topic or how it affects you or society as a whole, or it might discuss or describe the unique terminology associated with the topic.The body of your paper should answer the questions posed in the problem. Explain how you approached and answered the question or solved the problem, and, for each question, show all steps involved. Be sure this is in paragraph format, not numbered answers like a homework assignment.The conclusion should summarize your thoughts about what you have determined from the data and your analysis, often with a broader personal or societal perspective in mind. Nothing new should be introduced in the conclusion that was not previously discussed in the body paragraphs.Include any tables of data or calculations, calculated values, and/or graphs associated with this problem in the body of your assignment. write a balanced chemical equation for the standard formation reaction of solid potassium permanganate What is the value of b:-8-b=-61) b=-22) b=2