Despite being desirable anticancer targets, there is no approach for finding such collateral lethal gene.
Recurrent loss-of-function deletions frequently inactivate tumor suppressor genes, but they also frequently result in the collateral deletion of vital genes nearby on the chromosome, leading to dependency on paralogs with preserved function. Despite being desirable anticancer targets, there is no approach for finding such collateral lethal gene. In this article, we provide the CLIM framework for collateral fatal gene discovery using metabolic fluxes and apply it to identify MTHFD2 as a collateral deadly gene in ovarian tumors with UQCR11 deletion. We demonstrate the non-canonical oxidative role of MTHFD2 in supplying mitochondria with NAD+ as well as how the paralogue metabolic pathway controls systemic metabolic activity while maintaining metabolic flux adjustment. By combining genome-scale metabolic flux data with machine learning from CLIM, we can determine how effective it is to target MTHFD2 despite various obstacles.
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How do these factors affect your sexual attitudes?
Sexual attitude may vary from person to person, as it involves individual thought, view and perspective about sexuality and it's related topics.
Factors such as religion, peer group, culture, media exposure or environment are some of the factors which shapes an individual's perspective about sexuality and sex related attitudes. Culture plays a huge role in shaping ideas and views, hence, individual's cultural attitude or perception may be shaped by the cultural stance of such individual on sexuality. Adopting friends who are open to and give credence to sexual subjects may define the sexual attitude which the individual adopts.Therefore, the stance or position of culture, peers or religion about sexual education, teaching or openness will impact one's sexual attitude.
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A 41-year-old woman, whom was recently diagnosed with Type 2 Diabetes, returns to your community clinic seeking additional advice on how to lose weight. She eats an omnivorous diet that includes occasional whole grains, few fruits and vegetables, and a high amount of processed snack foods. Nearly all of her meals come from take-out restaurants. She does not know how to cook but is willing to learn. Which of the following approaches is most likely to help her maintain sustainable behavior change to meet her goal?
The most likely approach to help the 41-year-old woman with Type 2 Diabetes maintain sustainable behavior change and meet her weight loss goal is to provide her with nutrition education, meal planning guidance, and cooking classes, while gradually transitioning her diet towards whole, unprocessed foods.
Nutrition Education: Start by providing the woman with comprehensive information about the relationship between diet, diabetes, and weight loss. Educate her about the importance of balanced nutrition, portion control, and the impact of different food choices on blood sugar levels.
Meal Planning Guidance: Collaborate with the woman to create a personalized meal plan that aligns with her dietary preferences and health goals. Emphasize the inclusion of whole grains, fruits, and vegetables while reducing processed snack foods. Help her understand the importance of incorporating a variety of nutrients in her meals.
Cooking Classes: Since the woman does not know how to cook but is willing to learn, offer cooking classes tailored to her dietary needs. Teach her basic cooking techniques, meal preparation, and recipe modification to make healthier versions of her favorite dishes. Gradually introduce her to cooking with whole ingredients and emphasize the benefits of home-cooked meals.
Gradual Transition: Help the woman gradually transition from her current take-out meals to home-cooked meals. Start with simple recipes and gradually increase the complexity as she gains confidence in her cooking skills. Encourage her to experiment with different flavors and ingredients to make healthy eating enjoyable.
Ongoing Support: Provide ongoing support and follow-up visits to monitor her progress, address any challenges or questions, and provide additional guidance. Encourage her to keep a food diary to track her eating habits and make necessary adjustments to her meal plan.
By combining nutrition education, meal planning guidance, cooking classes, and gradual transition, this approach aims to empower the woman to make sustainable behavior changes, develop healthier eating habits, and achieve her weight loss goals while managing her Type 2 Diabetes effectively.
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which is not a type of anxiety disorder
Answer:
Bipolar Disorder
Explanation:
A 14-year-old boy has ataxia. He is brought to the local emergency department, where he appears euphoric, emotionally labile, and a bit disoriented. He has nystagmus and hypersalivation. Many notice his abusive language. Which of the following agents is mostlikely responsible for his condition?
a. Alcohol
b. Amphetamines
c. Barbiturates
d. Cocaine
e. Phencyclidine (PCP)
The agent responsible for the condition of the boy is Phencyclidine (PCP).
Phencyclidine is also commonly referred to as angel dust. The drug causes mind-altering effects. Some of the effects of the drug include distorted sound perception, hallucinations, hyperactivity, violent behavior etc.
It is a recreational drug and can be taken through the mouth, smoked, or injected into the body system. .
Since the boy appears euphoric, emotionally labile, disoriented and has hypersalivation, then this is the effect of taking Phencyclidine.
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Type the correct answer in the box. Spell the word correctly.
Which virtue is obtained at the end of the following stage according to Erickson’s psychosocial theory?
The stage of Intimacy vs. Isolation occurs from eighteen to forty years of age. Successful completion of this stage provides the virtue of
.
Answer:
the answer is the successful com. of stage provides the virtue of contentment..
Explanation:
A nurse is teaching a newly licensed nurse about crushing medications. The nurse should explain that which of the following medications can be
crushed?
Answer:
Morphine 2.5 mg IV bolus PRN for incisional pain
When does a dancer take a step in hip hop basic step 1?
Answer:
the hop to dance step 2
Explanation:
hru and the rest are all the way in which you are not to have a chance for the future and how it will work be for me and I don't open for too anything time trouble think have will can a able in for west bathroom and I you know want you to me or what I
how do the factors of physical activity and supportive/unsupportive relationships impact the PIES growth and development of individuals in early childhood and early adulthood?
The factors of physical activity and supportive/unsupportive relationships impact the PIES growth and development of individuals in early childhood and early adulthood by helping to build strong bones and reduce symptoms of anxiety.
What is PIES?This is referred to as the framework for child development and the letters stands for the following below:
P=PhysicalI=IntellectualE=EmotionalS=SocialThe factors of physical activities such as running , walking will help build strong bones in the body of the individual and will also help to reduce symptoms of anxiety and depression when there is a supportive relationship by the parents or guardians and are therefore the ways in which it can impact the development of individuals in early childhood and early adulthood.
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an example in our community or area in
which we currently do or should practice sustainable development. Are we doing
a good or bad job at “using it without abusing it?” What should be done
differently?
Energy production is one of the areas that we can be able to practice sustainable development
What is sustainable development?
Sustainable development is exemplified by the use of renewable energy sources, such as solar, wind, or hydropower, to generate electricity. Numerous communities all around the world have started investing in renewable energy as a way to lessen their dependency on fossil fuels and their carbon effect.
This can be done by constructing wind farms, solar panel installations on rooftops, or hydroelectric power plants using nearby rivers and streams as the source of energy.
However, despite the use of renewable energy sources, achieving sustainable development still offers challenges.
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All of the following are true of dual enrollment courses and Advanced Placement® courses EXCEPT
both award credits toward high school graduation once the course is completed and passed
both guarantee actual college credits for the student once the course is completed and passed
both offer college-level courses that students can take to demonstrate subject mastery
both provide an opportunity for high school students to reduce future college costs
All of the following are true of dual enrollment courses and Advanced Placement courses except both offering college-level courses that students can take to demonstrate subject mastery.
What are Dual enrollment courses?This involves students taking courses concurrently at two separate institutions.
Both types of courses don't guarantee subject mastery which was why option C was chosen as the most appropriate choice.
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Healthcare professionals at different levels of the continuum of care will have
Answer:
In healthcare, the continuum of care is now being used to describe how healthcare providers follow a patient from preventive care.
Explanation:
Essentially a continuum of care is a system that provides a comprehensive range of health services, so that care can evolve with the patient over time. With the understanding that a patient's health may be most vulnerable during gaps in care, the continuum of care exists to ensure those gaps are filled.
please rate this
Why is it important to live in the present?
Answer:
it is important to live in the present by learning from the past
Explanation:
living in the past can affect your present and that of the people around you
Unit2 DB- Early Childhood Studies- How are NAEYC Code of Ethical Conduct and Post University Academic Integrity Policy similar
The NAEYC Code of Ethical Conduct and Post University Academic Integrity Policy share similarities in their aim to uphold ethical standards and promote integrity in their respective domains.
Both the NAEYC Code of Ethical Conduct and Post University's Academic Integrity Policy emphasizes the importance of honesty, fairness, and respect.
They provide guidelines and expectations for individuals within their respective contexts, be it early childhood education or academic pursuits, to act with integrity and adhere to ethical principles.
Both documents stress the importance of maintaining confidentiality and protecting the rights and welfare of others. They encourage professionals and students to respect the diversity of individuals and their perspectives while promoting inclusive and supportive environments.
Additionally, both the NAEYC Code and the Academic Integrity Policy emphasize the importance of responsible and accountable behavior. They discourage cheating, plagiarism, and dishonesty, promoting a commitment to personal and professional integrity.
Overall, the NAEYC Code of Ethical Conduct and Post University's Academic Integrity Policy align in their efforts to foster ethical behavior, uphold standards of integrity, and create environments conducive to learning, growth, and ethical practice.
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which of the following are responsible for recognzing a change a change system
The receptors are responsible for recognizing a change in the system.
In biological systems, the ability to sense and respond to changes in the environment is crucial for maintaining homeostasis and ensuring proper functioning. The process of recognizing a change in the system starts with specialized structures known as receptors. These receptors are designed to detect specific signals or stimuli and initiate a response.
Receptors can be found throughout the body and are specialized based on the type of stimulus they detect. For example, in the sensory organs such as the eyes, ears, nose, and skin, there are receptors that respond to light, sound, smell, and touch, respectively. These sensory receptors convert the external stimuli into electrical signals that can be interpreted by the brain.
Similarly, within the body, there are receptors that monitor internal conditions such as temperature, pH levels, blood pressure, and hormone concentrations. These receptors are located in various organs and tissues and are responsible for detecting changes in these parameters.
Once a change is recognized by the receptors, they send signals to the control center, which could be the brain or specific organs involved in regulating the system. The control center processes the information and initiates an appropriate response to restore balance or maintain the desired state.
Overall, receptors play a vital role in recognizing changes in the system by detecting specific signals or stimuli. They serve as the first step in the feedback loop that allows organisms to monitor and respond to their environment effectively.
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Which description indicates a problem with the social aspect of health?
A.
Alex is the captain of the soccer team and is very popular. He's a very picky eater, especially about vegetables.
B.
Barbara exercises regularly and eats nutritious food. She is very shy and keeps to herself all the time.
C.
Ross enjoys rock-climbing adventures with his four best friends. He enjoys junk food in moderation.
D.
Laney loves to spend the afternoon at the burger joint next to school with her friends. She dislikes exercise
The description that is indicates a problem with the social aspect of health is Barbara exercises regularly and eats nutritious food. She is very shy and keeps to herself all the time.
Option B is correct.
What is health?Health, is described according to the World Health Organization, is "a state of complete physical, mental and social well-being and not merely the absence of disease and infirmity".
The scenario above could indicate that Barbara could have a social anxiety disorder or needs to open up and socialize more with others.
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what are the procedure to follow in case of an outbreak of disaster and to prevent the food contamination especially milk products
When businesses produce goods ansld services that consumers do not want
Answer:
There's decline in demand.
Explanation:
When businesses produce goods and services that consumers do not want, people don't purchase the goods leading to losses.
Hope it helps .
An experiment can show:
OA. how changing a variable can affect behavior.
O B. how observations can be valid.
OC. wording bias.
OD. interviewer bias.
Answer:
A. how changing a variable can affect behavior.
Explanation:
An experiment can be defined as an investigation which typically involves the process of manipulating an independent variable (the cause) in order to be able to determine or measure the dependent variable (the effect).
Hence, an experiment can show how changing a variable can affect behavior.
This ultimately implies that, an experiment can be used by scientists to show or demonstrate how a condition causes or gives rise to another i.e cause and effect, influence, behavior, etc in a sample.
What aspect of health most frequently defines what we think of when we discuss health?
1.Social well-being
2.Happiness
3.Mental well-being
4.Physical well-being
Peter Smith is a 73-year-old male with mild Type 2 diabetes. He states that he has needed to urinate more frequently during the last 2 weeks, and he feels a burning sensation when he urinates. He has also been very tired lately. Based on the vital signs you measured and Peter’s current complaints, the physician ordered a fasting blood glucose and a urinalysis.
Answer:
The search results and Wikipedia summary provided do not include a specific question. However, based on the information given, it is likely that Peter Smith is experiencing symptoms of a urinary tract infection, which is a common issue for older men. The need to urinate more frequently and a burning sensation during urination are both typical signs of a urinary tract infection. Additionally, feeling tired or fatigued can also be a symptom of an infection. Given that Peter has type 2 diabetes, it is important to monitor and manage his blood glucose levels, as high blood sugar can increase the risk of infections. The physician has ordered tests to confirm whether Peter does have a urinary tract infection and may prescribe antibiotics or other treatments as necessary.
Explanation:
why did Milgram say that he was confident that he could find plenty of people in America that would behave the same way that the soldiers in the Nazi prison camps that exterminated 6,000,000 Jews during WW2?
what is your overall meaning of health
Answer: Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity.
Explanation:Health is a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity.”
Need helpppppppppppppppppp
Answer:
what answer sir what?...
how can i help you??
write the negative impacts of drug abuse
Some negative impacts of drug abuse-
addiction, overdose, poor health, debt, violence, etc.
Sorry it's short, I ran out of ideas
Answer:
It leads to this like bruises and auiside
Fresh foods generally do not keep as long as processed foods?
True or False!
Answer:
true!
Explanation:
Answer:
false
Explanation:
because i didn't know what you mean
Describe the body's 3 immune systems (Active, Passive, Natural) and how each helps prevent diseases and infections
I
Answer:
Explanation:
Active - the process of exposing the body to an antigen. Exposing the body will generate an adaptive response that takes a few days or weeks to develop and can be life long lasting.
Passive - it is provided when we are given antibodies to disease. Instead of producing the antibodies with the immune system, they are given. Like a newborn baby acquires immunity from the placenta.
Natural - it works to fight off pathogens before they begin an active infection. Sometimes it is not enough to stop the pathogen or the pathogen exploits the immune response and gets to the cells.
Why is shock so dangerous
Answer:
Shock is a life-threatening condition that occurs when the body is not getting enough blood flow. Lack of blood flow means the cells and organs do not get enough oxygen and nutrients to function properly. Many organs can be damaged as a result. Shock requires immediate treatment and can get worse very rapidly
Explanation:
Shock is a life-threatening condition that occurs when the body is not getting enough blood flow. Lack of blood flow means the cells and organs do not get enough oxygen and nutrients to function properly. Many organs can be damaged as a result.
According to the Moral Choices textbook, God's covenant with Abraham, referenced in Genesis 12:3, was specifically initiated to bless:
Group of answer choices
Abraham and his family
All peoples on earth
The Hebrew people
The nation of Israel
These promises from God are now being fulfilled: God will bless those who bless Abram. God will punish anybody who denigrates Abram. All the families, or “peoples,” of the earth will be blessed through Abram. Thus, option B is correct.
What God's covenant with Abraham?That is the last thing God said to Abram. Abram's response is revealed in the next passage.
In addition, God's promises in this passage are not predicated on Abram's deeds, obedience, kindness, or deservingness. God merely states that He will do these things for and through Abram.
Therefore, God's covenant with Abraham, referenced in Genesis 12:3, was specifically initiated to bless all people on earth.
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What is the primary value of a support group?
Answer:A support group provides an opportunity for people to share personal experiences and feelings, coping strategies, or firsthand information about diseases or treatments. For many people, a health-related support group may fill a gap between medical treatment and the need for emotional support.
Explanation:
What is an example of a baby’s cue for the need for nurturing and attention from a caregiver or parent
Answer:
i think probably crying
Explanation: