lu, h., saha, j., beckmann, p.j., hendrickson, e.a. and davis, a.j. (2019) dna-pkcs promotes chromatin decondensation to facilitate initiation of the dna damage response. nucleic acids res, 47, 9467- 9479.

Answers

Answer 1

In conclusion, the paper likely provides experimental evidence and analysis demonstrating that DNA-PKcs is involved in promoting chromatin decondensation, which facilitates the initiation of the DNA damage response. This research contributes to our understanding of the molecular mechanisms underlying DNA repair processes.

The provided citation is a research paper titled "DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response." The paper was published in the journal Nucleic Acids Research in 2019 by Lu, H., Saha, J., Beckmann, P.J., Hendrickson, E.A., and Davis, A.J.

Based on the title and authors, we can infer that the paper explores the role of DNA-PKcs in the process of chromatin decondensation, which is necessary for the initiation of the DNA damage response.

The DNA damage response is a cellular mechanism that detects and repairs damaged DNA, ensuring genomic stability.

To better understand the paper's findings and conclusions, it would be necessary to read the full text. However, we can assume that the research team investigated how DNA-PKcs (DNA-dependent protein kinase catalytic subunit) promotes chromatin decondensation, which is a crucial step in initiating the DNA damage response.

Chromatin decondensation refers to the relaxation of the compacted DNA structure known as chromatin, allowing easier access for repair proteins to the damaged DNA.

DNA-PKcs may play a role in this process, possibly by phosphorylating certain proteins or interacting with chromatin remodeling factors.

In conclusion, the paper likely provides experimental evidence and analysis demonstrating that DNA-PKcs is involved in promoting chromatin decondensation, which facilitates the initiation of the DNA damage response.

This research contributes to our understanding of the molecular mechanisms underlying DNA repair processes. Reading the full paper would provide more specific details and insights into the experiments and results obtained by the authors.

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Related Questions

Which product forms from the reaction between nitrogen (N)
(CI)?
A. NCI
B. NCI
C. N2CI
O D. N2C1

Answers

Answer:

None of the above

Explanation:

Because as N has the valence of 3 when it reacts with Cl of 1 as valence they will form NCl3

Answer:

The product of the reaction between nitrogen (N) and (CL) is nitrogen trichloride (NCl3)

Explanation:

Although by seeing the question's answer choices, I think it was an error to detect the question (image) by Brainly as 2 of the answers is written the same.

However, when nitrogen gas reacts with chlorine gas, the product is gaseous nitrogen trichloride (NCL3), I guess 1 of your answer must be NCL3.

when studying patterns of natural selection, when the middle range is favored, such as with human birth weights, this is disruptive selection.

Answers

False. Middle-range factors do not favor disruptive selection.

What is disruptive selection?

Disruptive selection occurs when extreme phenotypes are favored over the intermediate phenotype, leading to a bimodal distribution.

This means that individuals with traits on both ends of the spectrum have a selective advantage, while those with intermediate traits are at a disadvantage.

In the case of human birth weights, where the middle range is favored, it would be an example of stabilizing selection.

Stabilizing selection favors the intermediate phenotype and acts to reduce the variability in a population, maintaining the status quo.

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what is the frequency of the ib allele in this population? assume hardy-weinberg equilibrium

Answers

To determine the frequency of the ib allele in a population under Hardy-Weinberg equilibrium, more information is required, such as the frequency of the IA allele or the genotypic frequencies. Without this additional data, it is not possible to calculate the frequency of the ib allele.

Hardy-Weinberg equilibrium is a principle that describes the relationship between allele and genotype frequencies in a population that is not experiencing evolutionary forces. The equilibrium equation, p^2 + 2pq + q^2 = 1, relates allele frequencies (p and q) to genotype frequencies.

However, without knowing the frequency of the IA allele or the genotypic frequencies (AA, AB, or BB), it is not possible to determine the frequency of the ib allele alone. Additional information is needed to calculate the specific allele frequencies in the population.

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Complete the replicative cycle of a virus with a single-stranded genome that can function as mRNA.
(fig)

Answers

During a virus's single-stranded genome's replication cycle, infected cells release additional virus particles, which can then invade uninfected cells.

How can viruses with single-stranded RNA replicate?

One of two distinct methods—RNA-dependent RNA synthesis or, in the case of retroviruses, RNA-dependent DNA synthesis (reverse transcription) followed by DNA replication and transcription—is used by RNA viruses to replicate their genomes.

RNA viruses produce mRNA in what ways?

RNA polymerase encoded by the virus and packed inside the virion produces the mRNAs. Enzymes contained within the virion cap and methylate the RNA. After that, it is extruded from the capsid's vertices. The viral proteins produced by the translation of the mRNAs come together to form an immature capsid.

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Which of the following helps to capture the energy of the sun?

Answers

Chloroplasts

Chloroplasts capture the energy in sunlight and use it to synthesize energy-rich carbohydrates. This food made by chloroplasts provides the chemical energy needed by all forms of life. Mitochondria help cells to extract the energy in food molecules efficiently to power cellular activities.

he transcription of the information in DNA involves the pairing of the nitrogen bases of DNA with RNA nucleotides to form a molecule of messenger RNA.


Choose the RNA nitrogen bases that pair with the DNA nitrogen bases listed. Be sure to use the capital letters that represent the nitrogen bases.



A pairs with
.

C pairs with
.

T pairs with
.

Answers

In RNA:

A pairs with U

C pairs with G

T pairs with A

Answer:

U

G

A

Explanation:

edg2020

which of the following statements is most likely to be true regarding the embryonic stage of a product life cycle?a.a product in an embryonic stage has yet to gain widespread acceptance.b.the embryonic stage comes after the growth stage in a product's life cycle.c.during the embryonic stage, a product becomes technologically obsolete due to the stage of a product life cycle.d.a walkman is an example of a product that is currently in the embryonic stage.

Answers

The statement that is most likely to be true regarding the embryonic stage of a product life cycle is  A. a product in an embryonic stage has yet to gain widespread acceptance.

The embryonic stage is the beginning of the product's life cycle. At this stage, the product is still in its early stages of development and has yet to gain widespread acceptance. It is not yet widely available for purchase and is still in the process of being tested and evaluated by industry experts. During this stage, a product may not even have a name yet, and the company may be in the process of deciding on its final design and features. A walkman is not an example of a product that is currently in the embryonic stage, as it has been widely accepted and available for purchase for many years.

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the question are in the Picture:) Please help me :) ​

the question are in the Picture:) Please help me :)

Answers

Answer:

Birds

Explanation:

1. Wings

2. Flight feathers and beak

3. For survival purposes

What is likely to happen if a new organism that feeds off mice is introduced?
a.
The mice population will increase in response to the arrival of the new organism.
b.
The mice population, grasshopper population, and plant population will all increase.
c.
The new organism will compete with the snake population for resources.
d.
The populations of the existing organisms will remain unaffected.



Please select the best answer from the choices provided


A
B
C
D

Answers

Answer: A

Explanation:

this is correct because the mice population will decrease and would increase to prevent extinction

Supportive cartilage disappears from the bronchial tree at the level of the A. bronchioles. B. lobar bronchi. C. alveolar ducts. D. respiratory bronchioles

Answers

Supportive cartilage disappears from the bronchial tree at the level of D. respiratory bronchioles.

Respiratory bronchioles are the smallest bronchioles that conduct air in the lungs, they are the branches of the terminal bronchioles that subdivide into several tiny tubes called alveolar ducts. Each alveolar duct divides into several alveolar sacs, and each sac contains several alveoli that are the basic functional unit of the lung. Respiratory bronchioles are lined with cuboidal epithelium that lacks mucous glands and goblet cells. They have smooth muscle fibers in their walls that regulate air flow into and out of the lungs.

The supportive cartilage disappears from the bronchial tree at the level of respiratory bronchioles because their walls become thinner as they enter deeper into the lung tissue. The absence of cartilage in respiratory bronchioles enables them to dilate and constrict efficiently during respiration. Apart from respiratory bronchioles, cartilage rings are present in the walls of trachea, primary bronchi, and bronchioles.

Their presence helps to maintain airway patency and protect the airway from collapse during breathing. In contrast, the absence of cartilage in respiratory bronchioles allows them to collapse during expiration, increasing the efficiency of gas exchange between blood and air. So the correct answer is D. respiratory bronchiotes is the level supportive cartilage disappears from the bronchial tree.

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Which health factor is an individual unable to change?
A-nutrition
B-environment
C-inherited genes
D-cholesterol levels

Answers

Answer:

C-inherited genes

Explanation:

The health factor that an individual is unable to change is inherited genes, which is in Option C, as inherited genes are passed down from parents to their offspring and can influence an individual's health.

What are inherited genes?

Inherited genes are a fundamental aspect of an individual's biology that they are born with and cannot change. These genes provide the blueprint for the development and functioning of various systems in the body, including the immune system, cardiovascular system, and nervous system. Some genetic traits can increase an individual's risk of developing certain diseases or conditions, while others may protect against certain health problems. While individuals cannot change their inherited genes, they can take steps to manage their health based on their genetic risk factors.

Hence, a health factor that an individual is unable to change is inherited genes, which is in Option C.

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comment on the number of white colonies on your plates: are they more abundant than blue colonies? what determines the ratio of white versus blue colonies on the plate?

Answers

To comment on the number of white colonies on your plates and compare their abundance to blue colonies, we need to consider the factors that determine the ratio of white versus blue colonies on the plate.

1. Observe the plates: Count or estimate the number of white and blue colonies present on each plate.

2. Compare the numbers: Determine if white colonies are more abundant than blue colonies by comparing the counts or estimates from step 1.

3. Analyze the determining factors: The ratio of white versus blue colonies on the plate may depend on factors such as the presence of specific selection markers, growth conditions, or genetic modifications in the organisms (e.g., bacteria) present on the plate. If white colonies represent organisms with a specific marker or gene, their abundance compared to blue colonies would depend on the frequency of that marker or gene in the population, as well as any selective pressure or growth advantage it may confer.

In summary, to comment on the abundance of white colonies compared to blue colonies on your plates, observe and compare the number of colonies of each color, and consider the factors that may determine their ratio, such as selection markers, growth conditions, or genetic modifications.

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what is genus? Write with example​

Answers

Answer:

A genus consists of a large number of organisms, whereas species consists of a fewer number of organisms. The best example is animals like zebra, horses, and donkeys which belong to the same Genus “Equss”. Meaning all the different species of zebra, donkey, and horses all belong to Equss.

Explanation:

Answer:

The genus is the generic name that includes closely related species; the gray wolf, for example, is classified as Canis lupus and is a close relative of the coyote found in North America and designated as Canis latrans, their systematic relation indicated by their sharing the same genus name, Canis.

having a narrow geographic distribution can protect a species from extinction when challenged by a changing environment. group of answer choices true false\

Answers

The given statement, "Having a narrow geographic distribution can protect a species from extinction when challenged by a changing environment," is false because narrow geographical distribution will result in more competition and hence extinction.

Extinction is the complete disappearance of the organisms of a species from all the habitats existing in the world. A species is said to be extinct when the last living organism dies out. It can happen due to several reasons like habitat changes, over-exploitation, competition, etc.

Competition is the interaction type where two or more species fight over the same resources or habitat. Competition can either harm both the species or it may benefit one and harm the other.

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The study of the flow of energy and its transformations is called:.

Answers

The study of the flow of energy and its transformations is called thermodynamics.

Hope this helped!

yoar until full yesting is reached at the end of the 7th yoar. True Falsec

Answers

The statement "Yoar until full yesting is reached at the end of the 7th yoar" is false because it contains multiple errors.

Firstly, the word "yoar" is likely a misspelling of the word "year." Secondly, the phrase "until full yesting is reached" is unclear and doesn't convey a meaningful idea. Additionally, the repetition of the word "yoar" at the end of the statement appears to be another typographical error.

Overall, the statement lacks coherence and logical consistency, making it impossible to identify a specific reason for its falsehood. It is important to ensure clear and accurate communication to convey accurate information and avoid confusion or misunderstanding or multiple errors.

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What is the first interaction that triggers cell signaling.

Answers

Cell signaling is the method by which cells exchange data and communicate with one another to regulate various cellular processes. The cells interact in a variety of ways, resulting in a diverse range of cell signaling pathways. There are three primary stages involved in cell signaling.

The first stage in cell signaling is the interaction of a ligand molecule with a receptor molecule. The ligand binds to the receptor on the cell surface and triggers a response, initiating the cell signaling cascade, which can lead to the activation of various signaling pathways that control numerous cellular processes. These ligand-receptor interactions are critical to cell signaling, as they serve as the primary trigger for the signaling pathway. Cells receive and respond to signals by initiating specific signaling pathways that lead to changes in gene expression, cell metabolism, and behavior.

Cell signaling plays a crucial role in regulating a variety of cellular processes, including cell differentiation, proliferation, apoptosis, and cell migration. Various signaling pathways and interactions are used by cells to communicate, allowing them to respond to changes in their environment and to adapt to these changes in various ways. Overall, the interactions that initiate cell signaling are critical for a wide range of cellular functions, including development, growth, and homeostasis.

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Which statement about cellular respiration is true?
SERE
O it produces oxygen.
O It requires water.
It is used by every living cell.
O It converts energy to food.

Answers

Answer:

It is used by every living cell

when a child is upset, parents can respond in many different ways. what kinds of emotion coaching are most likely to promote constructive emotional self regulation

Answers

The most effective emotion coaching techniques for promoting constructive emotional self-regulation in children are empathy, validation, and problem-solving.

Empathy involves acknowledging the child's feelings and showing understanding, which helps the child feel supported and less alone in their emotions. Validation refers to recognizing the legitimacy of the child's emotions, demonstrating that their feelings are important and normal. Problem-solving involves helping the child identify coping strategies or solutions to manage their emotions effectively.


In summary, when a child is upset, parents can best promote constructive emotional self-regulation by utilizing empathy, validation, and problem-solving techniques in their emotion coaching approach.

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The small structures within the cytoplasm of a eukaryotic cell that performs specific functions are called ______.

Answers

The small structures within the cytoplasm of a eukaryotic cell that performs specific functions are called  organelles.

What are organelles ?

Organelles are specialized organelles that carry out particular tasks in eukaryotic cells. The nucleus, which houses the genetic material of the cell, the mitochondria, which produce the energy for the cell, the lysosomes, which degrade waste products, the endoplasmic reticulum, and the Golgi apparatus are some examples of organelles (which are involved in protein synthesis and modification).

Each organelle has a distinct shape and function, and together they enable the cell to carry out all of its essential tasks, from energy production to protein and lipid synthesis. One of the primary distinctions between eukaryotes and prokaryotes (such as bacteria), which lack these specialized structures, is the existence of organelles in eukaryotic cells.

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How are the three domains, Bacteria, Archaea,
and Eukarya different?

Answers

Answer:

All of life can be divided into three domains, based on the type of cell of the organism: Bacteria: cells do not contain a nucleus. Archaea: cells do not contain a nucleus; they have a different cell wall from bacteria. Eukarya: cells do contain a nucleus.

Explanation:

Answer:All of life can be divided into three domains, based on the type of cell of the organism: Bacteria: cells do not contain a nucleus. Archaea: cells do not contain a nucleus; they have a different cell wall from bacteria. Eukarya: cells do contain a nucleus

Explanation:

Which of the following are the fundamental embryonic tissues called the "germ layers"?
A.tissues, organs, and organ systems. B.mesoderm, muscle, and tissue
C.ectoderm, endoderm, and exoskeleton D.mesoderm, endoderm, and ectoderm
E.mesoderm, exoderm, and hydroderm

Answers

The fundamental embryonic tissues called the "germ layers" are composed of D. mesoderm, endoderm, and ectoderm.

These three layers give rise to all the tissues and organs in the body.

The mesoderm forms the muscles, bones, blood vessels, and connective tissues.

The endoderm gives rise to the internal organs such as the lungs, liver, and digestive system.

Finally, the ectoderm forms the skin, nervous system, and sensory organs.

These three layers are essential in the early stages of embryonic development as they are responsible for the formation of the body plan.

They give rise to all the different tissues that make up the body, which later differentiate into organs and organ systems.

Therefore, option D, which includes the mesoderm, endoderm, and ectoderm, is the correct answer. The other options are not related to the fundamental embryonic tissues or the germ layers.

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Why are zebra mussels a problem in the Great Lakes but not in the lakes systems where they came from?

Why are zebra mussels a problem in the Great Lakes but not in the lakes systems where they came from?

Answers

Answer:

B. They have natural predators in the other lakes.

Explanation:

I'm pretty sure that's it, because if it's the lakes they originally came from, then they'd have predators to even their population out.

which of the following best predicts how the smooth endoplasmic reticulum (ser) and the rough endoplasmic reticulum (rer) will interact within a cell?

Answers

The smooth endoplasmic reticulum (SER) and the rough endoplasmic reticulum (RER) are involved in different processes within the cell, and their interaction depends on the cell's specific needs. the SER provides the RER with the lipids required for membrane synthesis.

The SER is responsible for lipid metabolism, whereas the RER is responsible for protein synthesis and folding. As a result, the SER provides the RER with the lipids required for membrane synthesis. The endoplasmic reticulum (ER) is a network of membranes that extends from the nucleus throughout the cytoplasm. It's divided into two types, the rough endoplasmic reticulum (RER) and the smooth endoplasmic reticulum (SER), which differ in their structure and function. The RER is studded with ribosomes, which give it a rough appearance. Ribosomes are involved in protein synthesis, and the RER is responsible for the production and folding of proteins. The SER, on the other hand, lacks ribosomes and appears smooth. The SER is involved in lipid synthesis, detoxification, and the storage of calcium ions. The interaction between the SER and RER within a cell is dependent on the cell's requirements. In certain cells, the RER may need lipids from the SER for the production of cell membranes. In such a situation, the SER will supply the RER with the required lipids. As a result, option 1 is the best predictor of how the SER and RER will interact within a cell.

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complete question: which of the following best predicts how the smooth endoplasmic reticulum (ser) and the rough endoplasmic reticulum (rer) will interact within a cell?

1. The SER will provide the RER with lipids for membrane synthesis.

2. The SER will transport materials around the cell for the RER to process.

3. The SER will provide the RER with proteins for folding and modification.

4. The RER will provide the SER with energy for processes

Assignment 2
1. In a tabular form, outline the functions of the following parts of the human respiratory
system
a. Nasal passages
b. Nasal hair
C. Mucus membrane
d. Pharynx
e. Epiglottis
f. Glottis
g. trachea
h. Rings of cartilages
i Larynx
j. Alveoli



please help ​

Answers

Answer:

a. The function of the nasal cavity is to warm, moisturize, and filter air entering the body before it reaches the lungs. Hairs and mucus lining the nasal cavity help to trap dust, before it reached the inner portions of the body.

b. It filtered the air to protect you from illness  irritation of the respiratory tract

c. It traps smaller particles like pollen or smoke.

d. It  regulate the passage of air to the lungs and food to the esophagus. The   throat, is the passageway leading from the mouth and nose to the esophagus and larynx.

e. It seal off the windpipe during eating, so that food is not accidentally inhaled.

f. Glottis opens into the windpipe and is responsible for the production of sound

g. It serves as passage for air and warms it while it passes into the lungs, and protects the respiratory surface from an accumulation of foreign particles.

h. It helps support the trachea while still allowing it to move and flex during breathing.

i. It  produces vocal sounds and prevents the passage of food and other foreign particles into the lower respiratory tracts.

j. It takes up the oxygen you breathe in and keep your body going.

Explanation:

What is__________Cell?

What is__________Cell?

Answers

Answer:

Explanation:

pLANt cell

Fatty acids required in the diet of mammals are called O a. Essential lipids O b. Dietary lipids ☆ O c. Saturated lipids O d. Important lipids O e. Esters

Answers

The correct answer is B. Dietary lipids.

Fatty acids required in the diet of mammals are commonly referred to as dietary lipids. These are essential components of the diet as they play important roles in energy storage, insulation, and the synthesis of various cellular components. Dietary lipids can include both saturated and unsaturated fatty acids, which are obtained from sources such as oils, fats, and certain food groups. These lipids are essential because mammals cannot synthesize certain fatty acids on their own and must obtain them from their diet.

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Which of the following disorders is caused by a defect in the production of an elastic connective tissue protein called fibrillin?
cystic fibrosis
Tay-Sachs disease
Marfan syndrome
Huntington disease
sickle-cell disease
Marfan syndrome is caused by a defect in the production of an elastic connective tissue protein called fibrillin.

Answers

Marfan syndrome is a genetic disorder that affects the body's connective tissue, which provides support and structure to various organs and tissues. The correct option is" Marfan syndrome is a disorder caused by a defect in the production of an elastic connective tissue protein called fibrillin".

Marfan syndrome is caused by mutations in the gene responsible for producing the protein called fibrillin-1. Fibrillin is a critical component of connective tissue and is involved in maintaining the strength and flexibility of various body structures, including the heart, blood vessels, bones, joints, and eyes.

Individuals with Marfan syndrome often have tall stature, long limbs, and flexible joints. They may also have various cardiovascular abnormalities, such as aortic aneurysms or valve problems. Other common features include a long, narrow face, a high-arched palate, a curved spine (scoliosis), and lens dislocation in the eye.

The correct option is "Marfan syndrome is a disorder caused by a defect in the production of an elastic connective tissue protein called fibrillin".

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Organisms developed _________ that provided its own food source.​

Answers

Answer:

autotrophic

Explanation:

An autotroph is an organism that can produce its own food using light, water, carbon dioxide, or other chemicals. Because autotrophs produce their own food, they are sometimes called producers. Plants are the most familiar type of autotroph, but there are many different kinds of autotrophic organisms.

Answer:

Explanation:

An autotroph is an organism that can produce its own food using light, water, carbon dioxide, or other chemicals.

What will most likely happen if a person does not consume the minimum daily requirement of carbohydrates?

Answers

If a person does not consume the minimum daily requirement of carbohydrates then the body will use stored glycogen and the person will look unhealthy and become weak after some time.

Importance of carbohydrates: Like other nutrients, carbohydrates are also very essential for various functions of the body. Carbohydrates such as glucose are required for instant energy and day-to-day activities. If there is no or less amount of carbohydrate in the body then our body will start converting the glycogen that is stored in the liver into glucose. After some time, the person will start to appear unhealthy, thin and weak if there is no minimum daily requirement of carbohydrates is met.

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Other Questions
_______________________only occur in the Northern Hemisphere, as the Southern Hemisphere has no landmasses at appropriate latitudes (between 40 and 70) A) Tropical A climates B) Dry climates (B) C) Mid latitudes climates (C) D) Severe Mid latitude climates (D) How do you find the input distance what caused political paralysis in the gilded age four and four fifths times a number is one and one fifth (write that as an equation) a nurse is caring for a client who is 6 hr postoperative and has a chest tube in place that is attached to a closed-chest water-seal drainage system. According to Section 4, the President, Vice President, and all civil officers shall be removed from office for high and . Mr Roman drove from his hometown to another city. He used 12 1/4 gallons of gas for 318 1/2 mile trip. On average, how many miles did Mr. Roman travel per gallon of gas Find the area of the composite figure.Round to the nearest hundredth.(10 Points)20.9m14.3m22.7 m 2) To move the camera toward or away from an object is called:A) ArcB) DollyC) PanD) Tilt If you were doing inquiry on new farming techniques used to farm in dry areas, which would be the BEST question to help you deepen your understanding of the topic?A) What is the history of farming technology?B) What kinds of technology is used to farm in dry areas?C) How can farming in dry areas help the global food supply?D) None of these questions would help you deepen your inquiry into a topic at all. HELPPPPP1. How can you prove that a line parallel to one side of a triangle divides the other 2 sides proportionally?2. In an isosceles triangle, how do you prove the base angles are congruent? PLEASE HELP!ITS INTEGRATED SCIENCE 6CO2 + 6H2O C6H12O6 + 6O2 Can you please identify the chemical equations with the correct process. complete the lewis structure for this species: co2 enter the total number of valence electrons in the box.valence electrons: Its part of a positive or negative and part B what does C equals Please tell me the answer if u know Joel bought a new baseball glove for $24.00. He received a discount of 20% off the original price. Which fraction or decimal is equivalent to 20%? Use the following to answer questions 64-65: Figure: Monopoly Pricing and Output Decisions 45 40 MC 30 25 O Price and Cost (S) 15 10- 5 ATC MR 1 1 1 1 1 16 18 20 22 24 0 2 4 6 8 10 26 12 14 Output Usi TRUE/FALSE. At depths below 100 km, subduction zone earthquakes occur almost exclusively in the interior of the colder oceanic lithosphere, the heart of the subducting slab. when members of one sex compete with each other for access to mates.