Development of targeted recombinant polymers that can deliver siRNA to the cytoplasm and plasmid DNA to the cell nucleus.

Answers

Answer 1

The development of targeted recombinant polymers that can deliver siRNA to the cytoplasm and plasmid DNA to the cell nucleus is a significant advancement in gene therapy and genetic research. These polymers, also known as gene delivery vectors, are designed to safely and efficiently transport genetic material into specific cellular compartments.

To achieve this, researchers have developed various types of recombinant polymers with specific characteristics. For siRNA delivery to the cytoplasm, the polymer must possess the ability to form stable complexes with the siRNA, protecting it from degradation and facilitating its cellular uptake. Examples of such polymers include lipid-based nanoparticles, polyethyleneimine (PEI), and dendrimers.
On the other hand, for plasmid DNA delivery to the cell nucleus, the polymer needs to possess nuclear localization signals (NLS) that allow it to interact with nuclear transport machinery. These signals help the polymer-DNA complexes overcome the nuclear membrane barrier and enter the nucleus. One example of a polymer commonly used for this purpose is poly-L-lysine (PLL).
By engineering these recombinant polymers, researchers have been able to enhance their stability, specificity, and delivery efficiency. This has led to the development of sophisticated systems that can deliver genetic material more effectively, offering potential treatments for various genetic disorders and diseases.
In conclusion, the development of targeted recombinant polymers for delivering siRNA to the cytoplasm and plasmid DNA to the cell nucleus has revolutionized gene therapy. These polymers provide a means to specifically deliver genetic material to desired cellular compartments, opening up possibilities for treating genetic diseases and advancing our understanding of cellular processes.

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Related Questions

HELPPPPPP!
During which phase is the difference between animal and plant cell mitosis the most significant?
prophase
metaphase
anaphase
telophase
interphase

Answers

Answer:

Their main difference is how they form the daughter cells during cytokinesis. During that stage, animal cells form furrow or cleavage that gives way to formation of daughter cells. Due to the existence of the rigid cell wall, plant cells don't form furrows.

Explanation:

How could the loss of biodiversity affect humans?

How could the loss of biodiversity affect humans?

Answers

The loss of biodiversity could affect humans by leading to the loss of potential medicine, foods and products and is therefore denoted as option B.

What is Biodiversity?

This refers to the variations which exists between organisms which are present in different types of ecosystem.

Lack of variation means there will be shortage of organisms which have differences in their traits or features. This isn't ideal because these differences may be as a result of natural selection which makes them fitter therefore having more beneficial properties.

These are therefore the most appropriate ways in which the loss of biodiversity affect humans.

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D. Giraffes just started out with long necks and haven't changed. 6. The idea that each living species has descended with changes from other species over time is called A. descent with modification C. acquired traits B. struggle for existence D. artificial selection​

Answers

C is the correct answer

Answer:

A. descent with modification.

Explanation:

I hope this helped you!!

39.
Term Definition
insulin _____
A. increases blood sugar levels
thyroid _____
B. a gland that regulates metabolism
epinephrine _____ C.
decreases blood suga

Answers

Answer:

insulin decrease blood sugar (c.)

How would a decrease in the amount of nitrogen and phosphorous affect a community in an aquatic ecosystem?

O Atmospheric oxygen would decrease

O Primary consumer populations would increase

O Primary production would decrease

The rate of photosynthesis would increase

Answers

The decrease in the amount of nitrogen and phosphorus would lead to a decrease in primary production in the aquatic ecosystem. This is because nitrogen and phosphorus are essential nutrients that are necessary for photosynthesis, which is the process by which primary producers create organic matter.

Primary producers, such as algae and aquatic plants, require nitrogen and phosphorus to grow and carry out photosynthesis. Without these nutrients, their growth and productivity would be limited. This would lead to a decrease in primary production, which would have cascading effects throughout the food web.

Consequently, the decrease in primary production would affect the entire community, including primary consumers, which would also experience a decrease in their populations. Additionally, a decrease in primary production would lead to a decrease in atmospheric oxygen, as photosynthesis is a primary source of oxygen in the atmosphere.

A decrease in the amount of nitrogen and phosphorus would have significant negative impacts on the aquatic ecosystem, leading to a decrease in primary production, primary consumer populations, and atmospheric oxygen levels.

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Origin: lateral third of clavicle, acromion, and spine of scapula. Action: abduction, flexion and extension, medial and lateral rotation of arm * Deltoid Infraspinatus Supraspinatus Subscapularis

Answers

Answer:

The correct answer is - Deltoid

Explanation:

Deltoid muscles are thick triangular muscles that help in raising and rotating arm covers shoulder joints. It originates lateral third of the clavicle, inferiorly along the spine of the scapula to the acromion.

Deltoid muscles provide actions that include flexion and medial rotation, abduction, and extension, and lateral rotation at the shoulder joint. Deltoid means triangle or that has three sides as it has three originating sides.

How do most fossils form? Be sure to explain your
answer.

Answers

Answer:

Fossils are formed in many different ways, but most are formed when a living organism (such as a plant or animal) dies and is quickly buried by sediment (such as mud, sand or volcanic ash).

Cell replication is important for reproduction of body cells and reproduction of gametes. Which type of reproduction occurs only in gametes

Answers

Answer:

meiosis

Explanation:

meiosis occurs in reproductive organs

A one-year-old boy was listless, irritable, and sleepy. Encapsulated Gram-negative rods were cultured from his cerebrospinal fluid. His symptoms were caused by

Answers

Based on the information provided, The most likely cause of these symptoms is meningitis, which is an inflammation of the membranes surrounding the brain and spinal cord.



Encapsulated Gram-negative rods commonly associated with meningitis include bacteria like Haemophilus influenzae and Neisseria meningitidis. These bacteria have a capsule that helps them evade the immune system and cause infection. To confirm the diagnosis and identify the specific bacteria causing the infection, a cerebrospinal fluid culture is performed. The presence of encapsulated Gram-negative rods in the culture suggests a bacterial cause.
It is important to note that meningitis can be a serious condition and requires prompt medical attention. Treatment typically involves the administration of antibiotics to eliminate the bacteria causing the infection.

Therefore the cause is meningitis.

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what is involved in making a smear? multiple select question. air drying a liquid that has been placed on a glass slide. staining the slide background and then applying cells. spreading a thin film of suspended cells on a glass slide. applying a liquid suspension to a cover slip.

Answers

The methods that are involved in making a smear are staining the slide background and then applying cells and applying a liquid suspension to a cover slip.

i) Take bacteria by the loop. If it is solid media, add water to the slide and mix it with culture. If it is liquid media, no need to add water to the slide.

ii)Spread the taken culture on the coverslip.

ii)The smear is then fixed by drying. The drying can be done by room temperature, hairdryer, or by keeping it on warmer slides.

iv)Now, the smear is ready.

The fixed smear can be stained and visualized. This method is followed in gram staining as well. The staining procedure is not involved in smearing.

So, the correct options are B and D.

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Type the correct answer in each box. Use numerals instead of words. If necessary, use / for the fraction bar.
The following chemical equation shows the combustion of ethane. Balance the equation by filling in the coefficients.


C2H6 +
O2 →
CO2 +
H2O

Answers

Answer:

2,7. 4,6

Explanation:

2 C2H6. +. 7O2. ==. 4. CO2. +. 6 H2O

Note. In such questions balance C first then H and finally O

It will be easier

when does land breeze blow and why?​

Answers

A land breeze is a local nighttime and early morning wind that occurs along coasts and blows offshore (from the land out to sea). It arises at sunset when the sea surface is warmer than the adjacent land due to the land having a lower heat capacity and cooling off faster.

a build-up of k in the t-tubules can occur during periods of frequent muscle cell potentials. what will be the result?

Answers

During muscle cell contractions, potassium ions (K+) get expelled from the cell due to an increase in permeability of the plasma membrane.

This, in turn, leads to an increase in the concentration of potassium ions in the extracellular fluid, thereby creating an electrochemical gradient favoring the entry of K+ back into the muscle cell, i.e., through the T-tubules.

While at rest, the concentration of K+ within the cell is much higher than the concentration in the extracellular fluid. However, when muscle cells undergo frequent periods of contractions, the concentration gradient may reverse, resulting in the buildup of K+ within the T-tubules.

This, in turn, can disrupt the normal electrochemical gradient across the membrane, leading to a decrease in the transmembrane potential and, subsequently, muscle fatigue.The buildup of K+ in the T-tubules can also interfere with excitation-contraction coupling by disrupting calcium ion release from the sarcoplasmic reticulum (SR).

This, in turn, can impair muscle contractility, leading to weaker contractions and decreased force production.In conclusion, the buildup of K+ in the T-tubules can lead to muscle fatigue, weakened contractions, and decreased force production.

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why is water not advisable for cleaning a microscope?

Answers

Do not use water, alcohol or acetone as the oil is insoluble to these solvents. To remove other oily substances, i recommend using the detergent called Wisk and prepare a solution of 1 part Wisk to 100 parts water I usually use it . Hope it helps

Please help! Multiple choice question.

Please help! Multiple choice question.

Answers

i’m pretty sure it’s a. sorry if i’m wrong <3

Which wave has high enough energy to cause damage to skin and sometimes cancer?
a) visible light

b) ultraviolet rays

c) infrared rays

d) microwaves

Answers

The correct answer is B) ultraviolet rays

Question 14 (2 points) The process of evolution that involves a change in the DNA sequence that leads to evolutionary change is called natural selection. O mutation. genetic drift. migration.

Answers

The process of evolution that involves a change in the DNA sequence that leads to evolutionary change is called a mutation.

A mutation is a sudden and lasting alteration in the DNA sequence that can influence genetic variation. Changes in the DNA sequence can influence phenotype, which may or may not have an effect on an organism's fitness. Mutations occur spontaneously, either from errors in DNA replication or from exposure to mutagenic agents. Mutations may happen in either coding or non-coding regions of the DNA, and they can be either silent or expressed.

Evolution is a natural process that results in the gradual change of inherited characteristics in populations over generations. It is the process of alteration in the inherited characteristics of species over successive generations. In other words, it is the process of gradual changes that happen to species over time as they adapt to their environments. It can be defined as a change in the gene frequency in a population over time.

Types of Evolution 1. Natural Selection 2. Genetic Drift 3. Gene Flow 4. Mutation 5. Non-Random Mating 6. Admixture 7. Mutation Pressure 8. Genetic Draft 9. Bottleneck and Founder Effect 10. Sexual Selection the process of evolution that involves a change in the DNA sequence that leads to evolutionary change is called a mutation.

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Farmers in a community are complaining that their crops are being damaged by
insects they never had problems with before. Explain what might be causing
this problem

Answers

Answer:

Unavailability of biological agent.

Explanation:

The main cause of this problem is the unavailability of biological agent for that insects in that environment. biological agents are the organisms that controls other insects population by feeding on them. When a new insect is introduced in a particular environment and no bioagent is present for it, it greatly damaged the crops and destroys the field of the farmer.

what causes hair to grow

Answers

Answer:

hair grows from the root at the bottom of the follicle under your skin . the blood in your scales goes into the follicle and supplies oxygen add nutrients to the hair root which helps your hair grow. as your hair grows it will push through the skin and pass by an oil glands.

I believe it to help you???

Two separate species of squirrels have evolved after being separated by the Colorado River's erosion of the Grand Canyon. What type of speciation has occurred here?


A. Allopatric Speciation


B. Sympatic Speciation


C. Disruptive Selection


D. Group Behavior

Answers

Answer:

Option A

Explanation:

In this case the two species of squirrels have evolved when their combined population got divided into parts and was separated as a cause of natural calamity i.e Colorado River's erosion of the Grand Canyon, thereby forced to live in two different geographies and hence evolve differently from each other. The two geographies mentioned above remain disconnected by any natural barrier thereby restricting successful mating of the two population  groups of squirrels.

hence, option A is correct

Answer:

Allopatric Speciation is Correct for all future users.

Explanation:

What type of wave is light? And does it need a medium to travel through?

Answers

Answer: light is a eletromagnetic wave, no it does not need a medium

Explanation:

have a good day lad :)

Answer:

light arent a specific "type" of wave, but it refers to any wave/wavelength in the electromagnetic spectrum

and yes, it needs a medium, just like sound waves

Compare and contrast between transportation in human ànd plants.
Why transport in human is more effective than that in plants

Answers

Answer:

1)Plants do not have a circulatory system.

•Humans have a well defined circulatory system.

2)transportation in plants occurs through specialised tissue xylem and phloem.

•Transportation in humans occurs through a netwotk of blood vessels such as artery vein capillary.

3)In plants substances transported are water, minerals, sugars and amino acid.

•In humans substances transported are glucose, glycerol, minerals, vitamins, fatty acids, amino acids and hormones.

4)Transportation in plants in controlled by opening and closing of stomata.

•Transportation in humans is controlled by constriction or dilation of blood bessels.

-->■Transportation in humans is more effective than the plants because in humans there is a well defined circulatory system which is highly regulated.As transport occur through blood vessel , transportation can be regulated by dilation or constriction of blood vessel.But plant do not have such circulatory system.

BRAINLIST PLS

How do you calculate magnification on a light microscope?

Answers

Answer:

In order to ascertain the total magnification when viewing an image with a compound light microscope, take the power of the objective lens which is at 4x, 10x or 40x and multiply it by the power of the eyepiece which is typically 10x.

Magnification on a light microscope is calculated by multiplying the magnification of the eyepiece lens and the objective lens.

What is a light microscope?

It is a tool used in biological labs that uses visible light for the detection of microscopic materials. The microscope focuses on extremely small objects, invisible to the unaided eye and makes them visible.

The lenses are used to focus on a specimen and light is used to enlighten it. With respect to lenses, it also has an eyepiece lens and an objective lens like the compound microscope.

Unlike the compound microscope, which uses the reflecting light of a mirror to enlighten the specimen, the light microscope uses visible light.

There is a condensor between the stage and the light source to help focus the light on the slide.

The magnification of a microscope is the combination of an eyepiece lens, through which the observer sees and the objective lens, focusing on the object.

Therefore, magnification is obtained by multiplying the lower of an eyepiece lens and an objective lens.

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Which term describes the number of different species in an area?
Responses

A. Ecosystem

B. Habitat

C. Biodiversity

D. Biome

Answers

Answer:

Biodiversity

Explanation:

Biodiversity is the variety of life in a habitat or ecosystem

8.
Describe your knowledge of nanomaterials synthesis methods.

Answers

Nanomaterials are synthesized using different techniques that include physical, chemical, and biological methods. The type of method chosen depends on the application, morphology, and structure of the nanomaterial that is required.

Physical methods used in the synthesis of nanomaterials include laser ablation, high-energy ball milling, electron beam lithography, and thermal evaporation.

Chemical methods involve the reduction of precursors to form nanomaterials. Chemical reduction methods used include sol-gel, hydrothermal synthesis, co-precipitation, and solvothermal synthesis.

Biological methods involve the use of biological organisms such as bacteria, yeast, or fungi to produce nanomaterials. The synthesis of nanomaterials using biological organisms is referred to as green synthesis. The advantage of green synthesis is that it is cost-effective and environmentally friendly.

Nanomaterials synthesis is important in the development of new products and technologies in different fields, including energy, medicine, and electronics. It is also used in the production of catalysts, sensors, and biomedical applications.

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Which organelles are found in plant cells but not in animal cells?
O cell membrane, vacuole
O cell wall, chloroplasts
O cell wall, vacuole
O cell membrane, chloroplasts

Answers

Answer:

cell wall chloroplasts

Cell walls and chloroplast are the organelles that are found in plant cells but not in animal cells A hard structure situated outside the cell membrane is called a cell wall and it is present in plant cells.

The cell wall supports and shields the cell's structure. Cell walls do not exist in animal cells.

Chloroplasts, specialized organelles involved in photosynthesis, are another component of plant cells. The pigment chlorophyll, which is found in chloroplasts, absorbs light energy and uses it to synthesize glucose.

The photosynthesis process cannot be performed by animal cells because they lack chloroplasts.

Hence, the chloroplasts and cell walls are the organelles that are present in plant cells but not in animal cells.

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1
Select the correct answer.
If you double the voltage in a circuit and reduce the resistance by a factor of four, what will happen to the current?
O A.
B.
C.
OD.
It will double.
It will decrease by a factor of 2.
It will increase by a factor of 8.
It will decrease by a factor of 8.
Reset
Next

Answers

The correct answer is C.

We can use Ohm's law to solve this problem. Ohm's law states that the current in a circuit is equal to the voltage divided by the resistance:

I = V/R

If we double the voltage and reduce the resistance by a factor of four, we get:

V' = 2V

R' = R/4

Substituting these values into Ohm's law, we get:

I' = (2V)/(R/4)

Simplifying this equation, we get:

I' = 8I

So the current will increase by a factor of 8.

Smoking reduces the surfactant layer in the alveoli. This would cause which of the following to occur? (2 points)

A. Depressed macrophage activity

B. Destroyed red blood cells

C. Reduced ability of gases to diffuse through the water layer

D. Reduced ability of gases to enter or exit the alveolar space

Answers

I think it is A correct me if I’m wrong

A molten, sticky rock thant forces its way through a crack in the Earth’s crust

A.Lava
B.Lahar
C.Magma
D.Scoria

Answers

Answer:

Magma.

Explanation:

This magma can push through holes or cracks in the crust, causing a volcanic eruption. When magma flows or erupts onto Earth's surface, it is called lava. Like solid rock, magma is a mixture of minerals.

magma is the correct answer

Please can someone help me?

Please can someone help me?

Answers

The set of chromosomes in the diagram below which depicts nondisjunction is 21 and is therefore denoted as option A.

What is Nondisjunction?

Nondisjunction is referred to as the failure of the chromosomes to separate, which produces daughter cells with abnormal numbers of chromosomes.

In the diagram given, set of chromosomes in the diagram below which depicts nondisjunction is 21 due to the abnormal length and properties observed when properly viewed thereby making it the correct choice.

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